Neuroscience Community

The following overview present the scientific key questions and methods of the neuroscience community in Rostock. The information should lay the basis for joint projects and initiatives within the Centre for Transdisciplinary Neurosciences (CTNR).

Join us and get in contact with our neuroscience researchers for new projects and initiatives!

Ageing Research, Bioinformatics and Biostatistics

The Institute for Biostatistics and Informatics in Medicine and Ageing Research seeks to identify biomarkers for personalizing senotherapeutic, anti-fibrotic & anti-inflammatory drugs, as well as natural supplements & food. In the Neurosciences, we are specifically interested in biomarkers of health deterioration following ischemic stroke, as part of the SASKit study. Learning biomarkers by state-of-the-art bioinformatics emphasizes interpretability, based on omics data, in cooperation with our experimental & clinical partners, for the transcriptome, proteome, microbiome, and for molecular single-cell mechanisms. Unlike other bioinformatics groups, we are ourselves coordinating observational and interventional human trials, as well as a preclinical development effort. Precision prevention to maximize healthspan and compress morbidity is our goal as a member of all three profile areas of the Rostock University Medical Center, and of the Interdisciplinary  Department on Ageing of Individuals and Society (AGIS) of Rostock University.

Contact: Prof. Dr. Georg Fuellen

More Information

Anorexia nervosa

Our group is interested to understand the physiology and pathology of anorexia nervosa and its impact on the brain, especially the influence of glia cells in the complex process of food intake. Of note, astrocytes and microglia play active roles in feeding circuits in the hypothalamus, the center for regulating food intake. Therefore, glia cell changes and dysfunctions might contribute to the clinical symptoms of AN and thus are important new research targets for understanding and treating semi-starvation and AN. To answer our scientific questions, we use methods as design-based stereology, a set of behavioral analyses such as object recognition and open field tests, western blot and immunohistochemistry. Current research projects for students (medical doctor or bachelor/master thesis) are available.

Contact: Dr. rer. nat. Linda Frintrop

More Information

Cell Lab and PET Tracer Production

We conduct experimental research on cell cultures with small animals and the development of new PET tracer production processes.

Contact: Prof. Dr. med. Bernd Joachim Krause

More Information

Cellular Neurophysiology

The Work Group Cellular Neurophysiology is concerned with the generation and characterization of model systems of neurodegenerative diseases based on hiPSC technology. The focus is on patient-specific neural model systems, which are generated by hiPSCs from skin fibroblasts of NPC1 patients.

Contact: Dr. Moritz Frech

More Information

Cognition in ALS

Our aim is better describe cognitive/behavioral phenotypes in ALS and their role on disease pathogenesis using a combination of deep patient phenotyping with post mortem neuropathology.

Contact: Prof. Dr. J. Prudlo

More Information

Embryonic Neurogenesis

The research group on embryonic neurogenesis focuses on neuronal plasticity during brain development. The aim of our work is to investigate the influence of oxygen on embryonic neural stem cells and the formation of different brain regions to elucidate the underlying mechanism of oxygen-dependent neurogenesis.

Contact: Prof. Dr. med. Alexander Storch

More Information

Experimental Deep Brain Stimulation

The research group Experimental Deep Brain Stimulation is primarily interested in understanding the effects and mechanisms of action of deep brain stimulation in a model of Parkinson's disease. Our goal is to better characterize this treatment method, which has been available in clinical application for decades, and thus to contribute to an optimization of deep brain stimulation in Parkinson's patients in the future.

Contact: Dr. med. Mareike Fauser

More Information

Forensic Psychiatry

We are a young and developing research group concerned with the quality and effectiveness of interventions for mentally disordered offenders. How can we improve the quality of life of our patients who are detained potentially for many years? How can we help them develop protective factors and reduce their risk of reoffending after discharge? Which interventions are successful for whom? What are quality indicators for forensic-psychiatry? A particular interest of our group is patient involvement in treatment delivery as well as research.

Contact: Prof Dr med Birgit Völlm PhD MRCPsych DiplForPsych

More Information

Headache/Pain

The headache/pain working group focuses on scientific studies on the epidemiology and clinical characteristics of headache and facial pain, the mode of action and effectiveness of neuromodulating procedures in headache disorders, the pathophysiology of migraines and burning mouth syndrome (BMS) as well as disorders of the somatosensitive system in various diseases.

Contact: Dr. Florian Rimmele

More Information

History of Psychiatry and Neurology

The working group focuses on the role of psychiatry and neurology as part of the state-controlled health system of the German Democratic Republic (GDR). We are interested in the structures relevant for psychiatry and neurology within the GDR health care system in the period from 1945 to 1990. In the project "Psychiatry in the GDR between help, custody and abuse?" we investigate in cooperation with the Clinic of Psychiatry, University Medical Centre Greifswald, within the research network "Seelenarbeit im Sozialismus - SiSaP" the structural anchoring and social status of psychiatric care in the Soviet Occupation Zone and GDR.

Contact: Prof. Dr. med. Ekkehardt Kumbier

More Information

Late-Translational Dementia Research at DZNE

We perform methodological research in order to improve the efficiency of translation of scientific developments along the translational continuum up to their implementation in clinical practice. This entails adaptation of methodology to specific research fields, in order to improve its adoption among researchers and produce data that can be used in subsequent steps and eventually support decision making. The work also includes producing tools enabling the participation of different kinds of professionals and stakeholders, who need to communicate effectively and to overcome the hurdles of hyper-specialization characterizing many scientific research sectors.

Contact: Dr. Marina Boccardi

More Information

Medical Genetics

The Medical Genetics working group focuses on the development of innovative, cellular disease models with the aim of improving molecular diagnostic and prognostic methods and testing personalized, molecular therapeutic treatment approaches for patients with rare metabolic diseases.

Contact: Dr. Jan Lukas

More Information

Metabolic Syndrome and Neurodegeneration

The research focus is to characterize new biomarkers for neuronal dysfunction on the basis of changes in the brain structure and brain metabolites.

Contact: Prof. Dr. rer. nat. Angela Kuhla

More Information

Molecular Neurobiology

The group Molecular Neurobiology led by PD Dr. Luo focuses on understanding the mechanisms of neuron loss and dysmyelination in neurodegenerative disorders, e.g., Niemann-Pick type C1 (NPC1) disease, and exploring the potential for future therapeutic targets. We take a multi-systemic approach including pathophysiological analyses and state-of-the-art molecular biological techniques both in an in vivo mouse model of NPC1 and in vitro cell culture systems to investigate how the defective cholesterol metabolism induces neurodegeneration in NPC1 disease. 

Contact: PD Dr. Jiankai Luo

More Information

Movement Disorders and Deep Brain Stimulation

The working group deals with pathophysiological aspects of movement disorders, especially Parkinson's disease and dystonia, as well as the mode of action and therapy optimization of deep brain stimulation clinically in humans and in basic science.

In terms of methodology, in addition to clinical characterization, instruments from electrophyisology, imaging and nuclear medicine are used in a multimodal manner.

Contact: Dr. med. Matthias Löhle, PD Dr. med. René Reese

More Information

Multiple Sclerosis

Our group is interested to understand the physiology and pathology of the axon-oligodendrocyte-myelin unit. Particularly, we are interested to understand to what extend stressed oligodendrocytes regulate peripheral immune cell recruitment, and by which neuroanatomical pathways peripheral immune cells gain access into the CNS parenchyma. To address our scientific challenges we use state of the art techniques such as design-based stereology, a set of behavioral analyses such as high speed ventral plane videography, or positron emission tomography/computed tomography. Whenever possible, we compare our pre-clinical results with post-mortem samples, obtained from MS patient donors.

Contact: Prof. Dr. med. Dr. rer. nat. Markus Kipp

More Information

Neurogenetics

Our working group is particularly concerned with the genetic causes of movement disorders. One focus is on genetic causes of dystonia, on the one hand the rare monogenetically inherited forms such as DYT1 dystonia or paroxysmal dystonia (e.g. DYT9 or DYT18), on the other hand also the much more common sporadic focal dystonias (e.g. torticollis and blepharospasm), for the genetic ones susceptibility factors have been demonstrated.

Contact: PD Dr. Christoph Kamm

More Information

Neurological Intensive Care Medicine

The research spectrum on neurological intensive care medicine includes clinical studies as well as experimental investigations that deal with the mechanisms and therapeutic effects in critically ill patients in neurological intensive care medicine. The focus is on the treatment of status epilepticus, neurological complications of sepsis and the function of the gastrointestinal tract in the critically ill with neurological diseases.

Contact: PD Dr. med. Matthias Wittstock

More Information

Neurological Sleep Disorders

Our focus is particularly on the investigation of REM sleep behavior disorder as well as sleep disorders in neurodegenerative diseases such as idiopathic Parkinson’s syndrome, dementia and motor neuron diseases.

Contact: Dr. med. Wiebke Hermann

More Information

Neuropaediatric Research Group

The focus of our research is on drug therapy safety and social pediatric aspects in pediatric epileptology and developmen tal neurology. A second focus area is experimental research on pathomechanisms of epilepsy and on neuroprotection of the immature brain especially in neonatal hypoxic-ischemic encephalopathy.

Contact: Prof. Dr. Astrid Bertsche

More Information

(Experimental) Neurophysiology

The working group is particularly concerned with neurophysiological issues relating to interhemispheric connections in various clinical pictures.

Contact: PD Dr. M. Wittstock

More Information

Neurophysiology

In the field of research, the Institute of Physiology, within the two working groups Neurophysiology and Vegetative Physiology, deals with the development mechanisms of common neurological diseases such as epilepsy and dystonia, with the elucidation of learning processes in the brain, with the functioning of voltage-dependent channels in nerve and muscle tissue the regulation of blood flow and blood pressure as well as the basics of peripheral oxygen measurement.

Contact: Prof. Dr.med. Rüdiger Köhling and Dr. Falko Lange

More information

Neurophysiology at the Psychiatry

Working Groups:

  1. Pain
  2. Time perception / delay aversion
  3. EEG as a BioMarker for mental disorders

Contact: Prof. Dr. med. habil. Johannes Buchmann

More Information

Neuroproteomics/Connectomics

Neuroproteomics

The differential expression of proteins of cortical and sucortical regions are investigated by 2D-gelelectrophoresis and MS-identification. The analysis is performed over major points of postnatal (pp) development: 0-10 days pp, 14-21 days pp, 40 days pp and > 40 days pp. The differential expression of proteins from time step to time step should provide information of those proteins which are important for the differentiation of neuronal progenitor cells and the patterns of proteins of their exratracellular niches.

Connectomics

The connectome of the rat nervous system consists of connections between regions of the central and peripheral nervous system. Regions are considered at different levels of resolution down to particular populations of neurons and individual types of neurons. The connectome is characterized at different scales with regard to graph theoretical measures (neuroVIISAS). The connections are availbale in a database and we are continously developing new methods of visualization high dimensional data (visual analytics). The connectome is embeded in a neuroontology and fully linked with the all tract tracing reports of the rat nervous system. The connectome data can directly applied to computational neuroscience for population based simulation of the simulation engine NEST.

Contact: Prof. Dr. med. Oliver Schmitt

More Information

Neuroregeneration

Working groups:

  1. Niemann-Pick disease type C 1 - mouse model
  2. Neurodegeneration, basal ganglia interconnection and functional neurorehabilitation
  3. Parkinson's disease

Contact: Prof. Dr. med. Andreas Wree

More Information

Neurosonology

The scientific objective of this project is the development and validation of new applications of this imaging modality in the diagnosis and therapy of neurological diseases.

Contact: Prof. Dr. Uwe Walter

More Information

Translational Neurodegeneration

Our group aims on developing novel causative therapeutic approaches of neurodegenerative diseases using a bidirectional clinical translation approach with main focus on Amyotrophic Lateral Sclerosis and Frontotemporal Dementia and to effectively translate these in clinical practice by combining strategies for the reduction of pathological aging on the one hand together with specific therapies of neuro-degenerative mechanisms on the other hand.

Contact: Prof. Dr. Dr. Andreas Hermann

More Information

University Medicine Rostock

Anatomy

Lars-Ove Brandenburg

Professor, Group Leader

Group Neuroinflammation, Institute of Anatomy
University Medicine Rostock

Resesarch areas: Acute and chronic inflammation of the CNS

Website

Markus Kipp

Professor, Director

Institute of Anatomy
University Medicine Rostock

Research areas: Mechanisms of immune cell recruitment into the central nervous System, Mechanisms of remyelination, Astrocyte and microglia diversity

Website

Andreas Wree

Senior Professor

Institute of Anatomy
University Medicine Rostock

Research areas: Effects of intrastriatal botulinum neurotoxin-A in hemiparkinsonian rats

Website

Biostatistics and Informatics in Medicine and Ageing Research

Georg Fuellen

Professor, Director

Institute for Biostatistics and Informatics in Medicine and Ageing Research
University Medicine Rostock

Research areas: Omics/Bioinformatics for Neuroregeneration/Neurodegeneration research

Website

Henrik Rudolf

Postdoctoral researcher

Institute for Biostatistics and Informatics
in Medicine and Ageing Research
University Medicine Rostock

Research areas: Statistical Methods in Clinical Trials, Multi-state Models, Stepped-wedge Designs

Website

Diagnostic and Interventional Radiology

Marc-André Weber

Professor, Director

Institute of Diagnostic and Interventional Radiology
University Medicine Rostock

Research areas: Functional imaging including perfusion and diffusion MR imaging, MR spectroscopy, non-proton MR imaging, contrast-enhanced ultrasound, hybrid imaging, dose reduction in radiology, functional CT imaging

Website

Experimental Gene Therapy and Cancer Research

Brigitte M. Pützer

Professor, Director

Institute of Experimental Gene Therapy and Cancer Research
University Medicine Rostock

Research areas: Translational biomedicine, molecular and epigenetic mechanisms of cancer progression, metastasis and chemotherapy resistance (E2F transcription factor signaling networks, p53/p73 signaling and functional genomics), tumor and stem cell reprogramming, development of gene and RNA-based therapeutics, Drug repositioning, genome editing technologies, Customized adenoviral and lentiviral gene transfer systems, tumor and stem cell targeting for personalised medicine

Website

Experimental Surgery

Angela Kuhla

Professor

Rudolf-Zenker-Institute for Experimental Surgery, University Medicine Rostock, Germany

Research areas: metabolic syndrome, neurodegeneration, dementia, Alzheimer disease, caloric restriction, fgf21, hepatic-neuronal communication, lipid metabolism

Website

Brigitte Vollmar

Professor, Director

Rudolf-Zenker-Institute for Experimental Surgery
University Medicine Rostock

Research areas: metabolic syndrome, neurodegeneration, dementia, Alzheimer disease, caloric restriction, fgf21, hepatic-neuronal communication, lipid metabolism

Website

Forensic Psychiatry

Birgit Völlm

Professor, Director

Forensic Psychiatry
University Medicine Rostock

Research areas: Neurobiology of personality disorders and social cognition, Forensic psychiatry

Website

Hematology, Oncology and Palliative Medicine

Christian Junghanß

Professor, Director

Department of Internal Medicine, Medical Clinic III
Universitätsmedizin Rostock

Research areas: Palliative Care Research, Oncology

Website

History of Medicine

Ekkehardt Kumbier

Professor, Director

History of Medicine
University Medicine Rostock

Research areas: Geschichte der Psychiatrie und Neurologie sowie medizinischen Forschung, einschließlich ethischer Implikationen, Geschichte der Neurowissenschaften, im 20. Jahrhundert, Wissenschaftsgeschichte

Website

Legal Medicine

Andreas Büttner

Institute of Legal Medicine
University Medicine Rostock

Research areas: (Forensic) Neuropathology, Forensic and genetic-neurobiologic aspects of illegal drug abuse, Forensic and genetic-neurobiologic aspects of suicide

Website

Medical Biochemistry and Molecular Biology

Simone Baltrusch

Professor of Biochemistry, Associate Director 

Institute of Medical Biochemistry and Molecular Biology
University Medicine Rostock

Research areas: Diabetes, Metabolic Syndrome and Aging with special emphasis on Beta-cell stimulus – secretion coupling, mitochondrial function and dynamics, mitochondrially mediated organ aging, development and signally of advanced glycation end products, diabetic neuropathy; Methodological focus: High resolution microscopy

Website

Markus Tiedge

Professor, Director

Institute of Medical Biochemistry and Molecular Biology
University Medicine Rostock

Research areas: Diabetes, Autoimmunity, Microbiome and Aging with special emphasis on beta cell destruction, mitochondrial function and dynamics, organ-specific signalling pathways of ROS Methodological focus: dynamics of mitochondrial oxygen consumtion; animal models of diabetes, microbiome analysis

Website

Medical Genetics

Carsten Holzmann

Postdoc

Institute of Medical Genetics 
University Medicine Rostock

Research areas: Neurodegenerative disases, Huntington's Disease (transgenic BACHD rat model), Niemann-Pick Type C1 (NPC1 mouse model), Parkinson's disease

Website

Medical Psychology and Medical Sociology

Peter Kropp

Professor, Director

Institute of Medical Psychology and Medical Sociology
University Medicine Rostock

Research areas: Attention, headache, migraine, behaviour therapy

Website

Neuroimmunology

Uwe Zettl

Professor, Section Head

Department of Neurology
Section Neuroimmunology
University Medicine Rostock

Research areas: Molecular pathomechanisms and biomarker research in multiple sclerosis

Website

Neurology

Kevin Peikert

Clinician Scientist

Neurology, University Medicine Rostock

Research areas: Hyperkinetic movement disorders, neuroacanthocytosis syndromes, VPS13-related disorders, VPS13/XK proteins, "bulk lipid transfer" in health and disease

Website

Alexander Storch

Professor, Director

Department of Neurology, University Medicine Rostock, Germany

Research areas: basic mechanisms of novel therapeutic approaches in Parkinson’s disease

Website

Uwe Walter

Professor, Deputy Director

Department of Neurology
University Medicine Rostock

Research areas: All applications of neurosonology, especially brain sonography, Preclinical diagnostics of Parkinson’s disease, Brain death concept and diagnostics, Stroke associated infections

Website

Neurosurgery

Thomas Freiman

Professor, Director

Department of Neurosurgery
University Medicine Rostock

Research areas: Oncology, Epilepsy, Neuroregenration

Website

Florian Geßler

Deputy Director, Senior Physician

Department for Neurosurgery
University Medicine Rostock

Research areas: Experimental Oncology, NeuroOncology, Neuromuscular Research

Website

Nuclear Medicine

Bernd Joachim Krause

Professor, Director

Department of Nuclear Medicine
University Medicine Rostock

Research areas: Molecular Imaging, PET/CT, Radiopharmacy, small ar:1imal PET/CT Imaging

Website

Otorhinolaryngology, Head and Neck Surgery

Robert Mlynski

Professor, Director

Dept. of Otorhinolaryngology, Head and Neck Surgery, ”Otto Koerner“
University Medicine Rostock

Research areas: active and passive middle ear implants, auditory pathway, plasticity and stem cell biology, lateral skull base disease including cholesteatoma, otosclerosis and acoustic neurinoma, quality of life with hearing disorders

Website

Physiology

Timo Kirschstein

Professor

Oscar-Langendorff-Intitute of Physiology
University Medicine Rostock

Research areas: Basic research and translational neurophysiology, Pathophysiology of epilepsy (animal models), Aging and cognition research

Website

Rüdiger Köhling

Professor, Director

Oscar-Langendorff-Institute of Physiology, University Medical Centre Rostock, University of Rostock

Research areas: Animal Models of neurological Diseases, Epileptology and Dystonia Research, Experimental Neurophysiology, Cellular and network functional plasticity

Website

Falko Lange

Postdoctoral researcher

Oscar-Langendorff-Institute of Physiology
University Medicine Rostock

Research areas: epilepsy, ischemic stroke, aging

Website

Psychiatry, Neurology, Psychosomatics, and Psychotherapy in Childhood and Adolescence

Christoph Berger

Research associate, technical chair of the neurophysiological lab

Department of Psychiatry, Neurology, Psychosomatics, and Psychotherapy in Childhood and Adolescence
University Medicine Rostock

Research areas: Imaging methods in neuroscience: task- and resting state-fMRI EEG-fmri, VBM; qEEG, ERP; (r-)TMS, eyetracking, other psychophysiological methods: facial emg, eda, hrv; chronobiological analyses; Theoretical background of research: interaction between motor cortical excitability and cognition, emotional and social perception

Website

Johannes Buchmann

Professor, Deputy Director, Chair of the Neurophysiological Research Laboratory

Department of Psychiatry, Neurology, Psychosomatics, and Psychotherapy in Childhood and Adolescence
University Medicine Rostock

Research areas: In childhood and adolescence: motor development, neurophysiological research laboratory (endogenously evoked potentials, inhibition / facilitation paradigms motor cortical evoked potentials), addiction, sleep, pain research, Fragile X Syndrome, intellectual disability

Website

Michael Kölch

Professor, Director

Department of Psychiatry, Neurology, Psychosomatics, and Psychotherapy in Childhood and Adolescence
University Medicine Rostock

Research areas: Affective Disorders of children and adolescents, traumatic experiences and impact on (mental) health, psychopharmacology, high risk populations for mental disorders

Website

Olaf Reis

Postdoctoral researcher

Department of Psychiatry, Neurology, Psychosomatics,
and Psychotherapy in Childhood and Adolescence
University Medicine Rostock

Research areas: developmental psychopathology: disorder and resilience on behavioural and systemic level (family, social support, social network), drug and sexual abuse and its prevention, intellectual disability

Website

Psychosomatics and Psychotherapeutic Medicine

Carsten Spitzer

Professor, Director

Department of Psychosomatics and Psychotherapeutic Medicine
University Medicine Rostock

Research areas: Psychotherapy research, Structural and personality disorders, Social cognition

Website

Stefan Teipel

Professor, Section Head

German Center for Neurodegenerative Diseases (DZNE),
Department of Psychosomatic and Psychotherapeutic Medicine
University Medicine Rostock

Research areas: Improving prediction, diagnosis, treatment and care of dementia

Website

 

Translational Neurodegeneration Section "Albrecht Kossel"

Moritz Frech

Group Leader Cellular Neurophysiology

Translational Neurodegeneration Section "Albrecht Kossel"
University Medicine Rostock

Research areas: Patient specific induced pluripotent stem cells and their neural derivatives for disease modelling and drug discovery

Website

Andreas Hermann

Professor, Section Head

Translational Neurodegeneration Section "Albrecht Kossel"
University Medicine Rostock

Research areas: Translational neurodegeneration, basic mechanisms of neurodegeneration and pathological aging

Website

Schilling-professorship and research group funded by the Hermann und Lilly Schilling-Foundation 

Jiankai Luo

Head of Molecular Neurobiology Unit

Translational Neurodegeneration Section "Albrecht Kossel"
University Medicine Rostock

Research areas: Neurodegeneration, Developmental Neurobiology, Stem cells

Website

Jan Lukas

Postdoctoral researcher

Translational Neurodegeneration Section "Albrecht Kossel"
University Medicine Rostock

Research areas: medical and functional genetics, characterisation and rescue of misfolded protein mutants in monogenic diseases of the metabolism

Website

University of Rostock

Animal Physiology

Fritz-Olaf Lehmann

Professor, Chair

Department of Animal Physiology
Institute of Biological Sciences
University of Rostock

Research areas: Neurobiology and Biomechanics of locomotion in Invertebrates, Drosophila Behavioral Genetics, Aerodynamics

Website

Marine Science Center

Frederike Hanke 

Professor

Marine Science Center
University of Rostock

Research areas: Sensory systems, mainly vision, of (semi)aquatic animals from periphery to central processing

Website

Lichtenberg Endowed Professorships funded by VolkswagenStiftung

Mobile Multimedia Information Systems

Thomas Kirste

Professor, Chair

Institute for Visual & Analytic Computing
Faculty of Computer Science and Electrical Engineering
University of Rostock

Research areas: Artificial Intelligence, Assistive Systems, Computational Behavior Analysis

Website

Systems Biology and Bioinformatics

Olaf Wolkenhauer

Professor, Chair

Systems Biology and Bioinformatics
Institute of Computer Science
Department of Systems Biology and Bioinformatics
University of Rostock

Research areas: Systembiologie, Bioinformatik, Systemmedizin, Data Science, Machine Learning, Image Analysis

Website

► Meet Our Members: 10 Questions to Prof. Wolkenhauer

Research Centre

German Center for Neurodegenerative Diseases (DZNE)

Marina Boccardi 

Group Leader

Late-Translational Dementia Research
German Center for Neurodegenerative Diseases (DZNE)

Research areas: Methodological studies aimed to improve the translation and implementation of neuroscience findings in clinical practice

Website

Meet Our Members

Sep. 27, 2022
10 Questions to Prof. Olaf Wolkenhauer (Systems Biology and Bioinformatics)

"Making inferences in face of uncertainty is what we get excited about"

mehr