About

Centre for Transdisciplinary Neurosciences Rostock (CTNR)

“Resilience in Neurodegeneration - from the model to the patient to the population” 

The University Medical Centre Rostock has a strong focus on transdisciplinary research in resilience and prevention of neurodegenerative diseases, and is one of the few institutions in Germany to systematically develop and use methods of participatory innovation in neurodegenerative brain diseases research.

In November 2017 the Centre for Transdisciplinary Neurosciences Rostock (CTNR) was founded to bundle the scientific activities of neurosciences and to improve the visibility and outcomes of the University Medical Centre in the field. The centre focuses on “Resilience in Neurodegeneration – from the model to the patient to the population” and represents one of the three main scientific areas (Forschungsschwerpunkte) at the University Medical Centre.

The overall scientific aim  of the CTNR is to identify and target resilience mechanisms in neurodegeneration to implement innovative therapeutic concepts for primary and secondary neurodegenerative processes.

CTNR creates an interface between clinical and basic research and improves the translational approach. Its concepts of educational training for clinician and medical scientist and funding programs cover the needs of the Neuroscience community.

Speaker

Prof. Dr. med. Alexander Storch

Department of Neurology
University Medicine Rostock

Co-Speaker

Prof. Dr. med. Rüdiger Köhling

Oscar-Langendorff-Institute of Physiology
University Medicine Rostock

Board Members

Prof. Dr.med. Dr.rer.nat. Markus Kipp

Institute of Anatomy
University Medicine Rostock

Apl. Prof. Dr. rer. nat. Angela Kuhla

Rudolf-Zenker-Institute for Experimental Surgery 
University Medicine Rostock

Prof. Dr. med. Attila Altiner

Institute of General Practice
University Medicine Rostock

Prof. Dr. rer. nat. Simone Baltrusch

Institute of Medical Biochemistry and Molecular Biology
University Medicine Rostock

Prof. Dr. med. Astrid Bertsche

Department of Neuropaediatrics/Neuropaediatric Research Group
University Medicine Rostock

Dr. Marina Boccardi, PhD 

Late-Translational Dementia Research
German Center for Neurodegenerative Diseases (DZNE)

Prof. Dr. rer. nat. Lars-Ove Brandenburg

Institute of Anatomy
University Medicine Rostock

Prof. Dr. med. Andreas Büttner

Institute of Legal Medicine
University Medicine Rostock

Dr. phil. nat. Moritz Frech

Translational Neurodegeneration Section "Albrecht Kossel"
University Medicine Rostock

Prof. Dr. med. Dr. med. Thomas Freiman

Department of Neurosurgery
University Medicine Rostock

Prof. Dr. rer. nat. Georg Fuellen

Institute for Biostatistics and Informatics
in Medicine and Ageing Research

University Medicine Rostock

PD Dr. med. Dr. med. habil. Florian Geßler, PhD, FEBNS

Department for Neurosurgery
University Medicine Rostock

Prof. Dr. Frederike Hanke 

Marine Science Center
University of Rostock

Prof. Dr. med. Dr. rer. med. Andreas Hermann

Translational Neurodegeneration Section "Albrecht Kossel"
University Medicine Rostock

 

Dr. rer. nat. Carsten Holzmann

Institute of Medical Genetics
University Medicine Rostock

PD Dr. med. Luo Jiankai

Translational Neurodegeneration Section "Albrecht Kossel"
University Medicine Rostock

Prof. Dr. med. Christian Junghanß

Department of Internal Medicine, Medical Clinic III
Universitätsmedizin Rostock

Prof. Dr. med. Timo Kirschstein

Oscar-Langendorff-Intitute of Physiology
University Medicine Rostock

Prof. Dr. Ing. Thomas Kirste

Faculty of Computer Science and Electrical Engineering
University of Rostock

Prof. Dr. med. Bernd Joachim Krause

Department of Nuclear Medicine
University Medicine Rostock

Prof. Dr. rer. soc. Peter Kropp

Institute of Medical Psychology and Medical Sociology
University Medicine Rostock

Prof. Dr. med. Ekkehardt Kumbier

History of Medicine
University Medicine Rostock

Dr. rer. nat. Falko Lange

Oscar-Langendorff-Institute of Physiology
University Medicine Rostock

Prof. Dr. Fritz-Olaf Lehmann

Department of Animal Physiology
Institute of Biological Sciences
University of Rostock
 

Dr. rer. nat. Jan Lukas

Translational Neurodegeneration Section "Albrecht Kossel"
University Medicine Rostock

Prof. Dr. med. Robert Mlynski

Dept. of Otorhinolaryngology, Head and Neck Surgery, ”Otto Koerner“
University Medicine Rostock

Prof. Dr. med. Dr. rer. nat. Brigitte M. Pützer

Institute of Experimental Gene Therapy and Cancer Research
University Medicine Rostock

Prof. Dr. med. Oliver Schmitt

Institute of Anatomy
University Medicine Rostock

Prof. Dr. med. Carsten Spitzer

Department of Psychosomatics and Psychotherapeutic Medicine
University Medicine Rostock

Prof. Dr. med. Markus Tiedge

Institute of Medical Biochemistry and Molecular Biology
University Medicine Rostock

Prof. Dr. med. Birgit Völlm

Forensic Psychiatry
University Medicine Rostock

Prof. Dr. med. Brigitte Vollmar

Rudolf-Zenker-Institute for Experimental Surgery
University Medicine Rostock

Prof. Dr. med. Uwe Walter

Department of Neurology
University Medicine Rostock

Prof. Dr. med. Marc-André Weber

Institute of Diagnostic and Interventional Radiology
University Medicine Rostock

Prof. Dr. med. Dr. h.c. Martin Witt

Institute of Anatomy
University Medicine Rostock

Prof. Dr. Olaf Wolkenhauer

Institute of Computer Science
Department of Systems Biology and Bioinformatics
University of Rostock

Prof. Dr. med. Andreas Wree

Institute of Anatomy
University Medicine Rostock

Prof. Dr. med. Uwe Zettl

Department of Neurology
Section Neuroimmunology
University Medicine Rostock

Working groups and research labs at the CTNR

Ageing Research, Bioinformatics and Biostatistics

The Institute for Biostatistics and Informatics in Medicine and Ageing Research seeks to identify biomarkers for personalizing senotherapeutic, anti-fibrotic & anti-inflammatory drugs, as well as natural supplements & food. In the Neurosciences, we are specifically interested in biomarkers of health deterioration following ischemic stroke, as part of the SASKit study. Learning biomarkers by state-of-the-art bioinformatics emphasizes interpretability, based on omics data, in cooperation with our experimental & clinical partners, for the transcriptome, proteome, microbiome, and for molecular single-cell mechanisms. Unlike other bioinformatics groups, we are ourselves coordinating observational and interventional human trials, as well as a preclinical development effort. Precision prevention to maximize healthspan and compress morbidity is our goal as a member of all three profile areas of the Rostock University Medical Center, and of the Interdisciplinary  Department on Ageing of Individuals and Society (AGIS) of Rostock University.

Contact: Prof. Dr. Georg Fuellen

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Anorexia nervosa

Our group is interested to understand the physiology and pathology of anorexia nervosa and its impact on the brain, especially the influence of glia cells in the complex process of food intake. Of note, astrocytes and microglia play active roles in feeding circuits in the hypothalamus, the center for regulating food intake. Therefore, glia cell changes and dysfunctions might contribute to the clinical symptoms of AN and thus are important new research targets for understanding and treating semi-starvation and AN. To answer our scientific questions, we use methods as design-based stereology, a set of behavioral analyses such as object recognition and open field tests, western blot and immunohistochemistry. Current research projects for students (medical doctor or bachelor/master thesis) are available.

Contact: Dr. rer. nat. Linda Frintrop

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Cell Lab and PET Tracer Production

We conduct experimental research on cell cultures with small animals and the development of new PET tracer production processes.

Contact: Prof. Dr. med. Bernd Joachim Krause

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Cellular Neurophysiology

The Work Group Cellular Neurophysiology is concerned with the generation and characterization of model systems of neurodegenerative diseases based on hiPSC technology. The focus is on patient-specific neural model systems, which are generated by hiPSCs from skin fibroblasts of NPC1 patients.

Contact: Dr. Moritz Frech

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Cognition in ALS

Our aim is better describe cognitive/behavioral phenotypes in ALS and their role on disease pathogenesis using a combination of deep patient phenotyping with post mortem neuropathology.

Contact: Prof. Dr. J. Prudlo

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Embryonic Neurogenesis

The research group on embryonic neurogenesis focuses on neuronal plasticity during brain development. The aim of our work is to investigate the influence of oxygen on embryonic neural stem cells and the formation of different brain regions to elucidate the underlying mechanism of oxygen-dependent neurogenesis.

Contact: Prof. Dr. med. Alexander Storch

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Experimental Deep Brain Stimulation

The research group Experimental Deep Brain Stimulation is primarily interested in understanding the effects and mechanisms of action of deep brain stimulation in a model of Parkinson's disease. Our goal is to better characterize this treatment method, which has been available in clinical application for decades, and thus to contribute to an optimization of deep brain stimulation in Parkinson's patients in the future.

Contact: Dr. med. Mareike Fauser

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Forensic Psychiatry

We are a young and developing research group concerned with the quality and effectiveness of interventions for mentally disordered offenders. How can we improve the quality of life of our patients who are detained potentially for many years? How can we help them develop protective factors and reduce their risk of reoffending after discharge? Which interventions are successful for whom? What are quality indicators for forensic-psychiatry? A particular interest of our group is patient involvement in treatment delivery as well as research.

Contact: Prof Dr med Birgit Völlm PhD MRCPsych DiplForPsych

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Headache/Pain

The headache/pain working group focuses on scientific studies on the epidemiology and clinical characteristics of headache and facial pain, the mode of action and effectiveness of neuromodulating procedures in headache disorders, the pathophysiology of migraines and burning mouth syndrome (BMS) as well as disorders of the somatosensitive system in various diseases.

Contact: Dr. Florian Rimmele

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History of Psychiatry and Neurology

The working group focuses on the role of psychiatry and neurology as part of the state-controlled health system of the German Democratic Republic (GDR). We are interested in the structures relevant for psychiatry and neurology within the GDR health care system in the period from 1945 to 1990. In the project "Psychiatry in the GDR between help, custody and abuse?" we investigate in cooperation with the Clinic of Psychiatry, University Medical Centre Greifswald, within the research network "Seelenarbeit im Sozialismus - SiSaP" the structural anchoring and social status of psychiatric care in the Soviet Occupation Zone and GDR.

Contact: Prof. Dr. med. Ekkehardt Kumbier

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Late-Translational Dementia Research at DZNE

We perform methodological research in order to improve the efficiency of translation of scientific developments along the translational continuum up to their implementation in clinical practice. This entails adaptation of methodology to specific research fields, in order to improve its adoption among researchers and produce data that can be used in subsequent steps and eventually support decision making. The work also includes producing tools enabling the participation of different kinds of professionals and stakeholders, who need to communicate effectively and to overcome the hurdles of hyper-specialization characterizing many scientific research sectors.

Contact: Dr. Marina Boccardi

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Medical Genetics

The Medical Genetics working group focuses on the development of innovative, cellular disease models with the aim of improving molecular diagnostic and prognostic methods and testing personalized, molecular therapeutic treatment approaches for patients with rare metabolic diseases.

Contact: Dr. Jan Lukas

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Metabolic Syndrome and Neurodegeneration

The research focus is to characterize new biomarkers for neuronal dysfunction on the basis of changes in the brain structure and brain metabolites.

Contact: Prof. Dr. rer. nat. Angela Kuhla

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Molecular Neurobiology

The group Molecular Neurobiology led by PD Dr. Luo focuses on understanding the mechanisms of neuron loss and dysmyelination in neurodegenerative disorders, e.g., Niemann-Pick type C1 (NPC1) disease, and exploring the potential for future therapeutic targets. We take a multi-systemic approach including pathophysiological analyses and state-of-the-art molecular biological techniques both in an in vivo mouse model of NPC1 and in vitro cell culture systems to investigate how the defective cholesterol metabolism induces neurodegeneration in NPC1 disease. 

Contact: PD Dr. Jiankai Luo

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Movement Disorders and Deep Brain Stimulation

The working group deals with pathophysiological aspects of movement disorders, especially Parkinson's disease and dystonia, as well as the mode of action and therapy optimization of deep brain stimulation clinically in humans and in basic science.

In terms of methodology, in addition to clinical characterization, instruments from electrophyisology, imaging and nuclear medicine are used in a multimodal manner.

Contact: Dr. med. Matthias Löhle, PD Dr. med. René Reese

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Multiple Sclerosis

Our group is interested to understand the physiology and pathology of the axon-oligodendrocyte-myelin unit. Particularly, we are interested to understand to what extend stressed oligodendrocytes regulate peripheral immune cell recruitment, and by which neuroanatomical pathways peripheral immune cells gain access into the CNS parenchyma. To address our scientific challenges we use state of the art techniques such as design-based stereology, a set of behavioral analyses such as high speed ventral plane videography, or positron emission tomography/computed tomography. Whenever possible, we compare our pre-clinical results with post-mortem samples, obtained from MS patient donors.

Contact: Prof. Dr. med. Dr. rer. nat. Markus Kipp

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Neurogenetics

Our working group is particularly concerned with the genetic causes of movement disorders. One focus is on genetic causes of dystonia, on the one hand the rare monogenetically inherited forms such as DYT1 dystonia or paroxysmal dystonia (e.g. DYT9 or DYT18), on the other hand also the much more common sporadic focal dystonias (e.g. torticollis and blepharospasm), for the genetic ones susceptibility factors have been demonstrated.

Contact: PD Dr. Christoph Kamm

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Neurological Intensive Care Medicine

The research spectrum on neurological intensive care medicine includes clinical studies as well as experimental investigations that deal with the mechanisms and therapeutic effects in critically ill patients in neurological intensive care medicine. The focus is on the treatment of status epilepticus, neurological complications of sepsis and the function of the gastrointestinal tract in the critically ill with neurological diseases.

Contact: PD Dr. med. Matthias Wittstock

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Neurological Sleep Disorders

Our focus is particularly on the investigation of REM sleep behavior disorder as well as sleep disorders in neurodegenerative diseases such as idiopathic Parkinson’s syndrome, dementia and motor neuron diseases.

Contact: Dr. med. Wiebke Hermann

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Neuropaediatric Research Group

The focus of our research is on drug therapy safety and social pediatric aspects in pediatric epileptology and developmen tal neurology. A second focus area is experimental research on pathomechanisms of epilepsy and on neuroprotection of the immature brain especially in neonatal hypoxic-ischemic encephalopathy.

Contact: Prof. Dr. Astrid Bertsche

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(Experimental) Neurophysiology

The working group is particularly concerned with neurophysiological issues relating to interhemispheric connections in various clinical pictures.

Contact: PD Dr. M. Wittstock

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Neurophysiology

In the field of research, the Institute of Physiology, within the two working groups Neurophysiology and Vegetative Physiology, deals with the development mechanisms of common neurological diseases such as epilepsy and dystonia, with the elucidation of learning processes in the brain, with the functioning of voltage-dependent channels in nerve and muscle tissue the regulation of blood flow and blood pressure as well as the basics of peripheral oxygen measurement.

Contact: Prof. Dr.med. Rüdiger Köhling and Dr. Falko Lange

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Neurophysiology at the Psychiatry

Working Groups:

  1. Pain
  2. Time perception / delay aversion
  3. EEG as a BioMarker for mental disorders

Contact: Prof. Dr. med. habil. Johannes Buchmann

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Neuroproteomics/Connectomics

Neuroproteomics

The differential expression of proteins of cortical and sucortical regions are investigated by 2D-gelelectrophoresis and MS-identification. The analysis is performed over major points of postnatal (pp) development: 0-10 days pp, 14-21 days pp, 40 days pp and > 40 days pp. The differential expression of proteins from time step to time step should provide information of those proteins which are important for the differentiation of neuronal progenitor cells and the patterns of proteins of their exratracellular niches.

Connectomics

The connectome of the rat nervous system consists of connections between regions of the central and peripheral nervous system. Regions are considered at different levels of resolution down to particular populations of neurons and individual types of neurons. The connectome is characterized at different scales with regard to graph theoretical measures (neuroVIISAS). The connections are availbale in a database and we are continously developing new methods of visualization high dimensional data (visual analytics). The connectome is embeded in a neuroontology and fully linked with the all tract tracing reports of the rat nervous system. The connectome data can directly applied to computational neuroscience for population based simulation of the simulation engine NEST.

Contact: Prof. Dr. med. Oliver Schmitt

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Neuroregeneration

Working groups:

  1. Niemann-Pick disease type C 1 - mouse model
  2. Neurodegeneration, basal ganglia interconnection and functional neurorehabilitation
  3. Parkinson's disease

Contact: Prof. Dr. med. Andreas Wree

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Neurosonology

The scientific objective of this project is the development and validation of new applications of this imaging modality in the diagnosis and therapy of neurological diseases.

Contact: Prof. Dr. Uwe Walter

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Translational Neurodegeneration

Our group aims on developing novel causative therapeutic approaches of neurodegenerative diseases using a bidirectional clinical translation approach with main focus on Amyotrophic Lateral Sclerosis and Frontotemporal Dementia and to effectively translate these in clinical practice by combining strategies for the reduction of pathological aging on the one hand together with specific therapies of neuro-degenerative mechanisms on the other hand.

Contact: Prof. Dr. Dr. Andreas Hermann

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United Neuroscience Campus Lund - Rostock

The idea is the formal and institutional networking of two internationally excellent neuroscientific locations with a large translational focus in order to establish a virtual campus beyond the Lund and Rostock locations on key neuroscience topics.

Schilling-Professorship and Research Group in the field of "Translational Neurosciences"

Successful grant application at the Hermann und Lilly Schilling-Foundation for the establishment of a Schilling-professorship and research group in the fiel of "translational neurosciences" at the Department of Neurology in cooperation with the DZNE. 

Newsletter about Funding Opportunities, Training and Events in Neurosciences

The monthly newsletter is a free service of the Centre for Transdisciplinary Neurosciences Rostock. It provides information about recent funding opportunities, awards, training opportunities and events in the field of neurosciences.

Research Group "Non-motor symptoms in Parkinson's disease and related disorders"

In cooperation with the DZNE and the Department of Neurology, Rostock University Medical Center. 

Participations at the Collaborative Research Centre 1270 ELAINE (ELectrically Active ImplaNts)

  • C03: Deep brain stimulation in dystonia models: Biological implementation, approximation of stimulation parameters and analysis of mechanisms (Project leader: Prof. Dr. med. Rüdiger Köhling, Oscar-Langendorff-Institute of Physiology, Rostock University Medical Centre)
  • C04: Effects of deep brain stimulation on adult neurogenesis in a rat model of Parkinson's disease: Mechanisms of action, stimulation parameters and correlation with behaviour (Project leader: Prof. Dr. med. Alexander Storch, Department of Neurology, Rostock University Medical Centre)
  • IRTG - Integrated Research Training Group (Advisor: Prof. Dr. med. habil. Alexander Storch, Department of Neurology, Rostock University Medical Centre)

Foundation of the Centre for Transdisciplinary Neurosciences Rostock (CTNR)

  • on 22th November 2017
  • Election of the CTNR Board and Members
  • Commencement of the CTNR bylaws
  • Launch of the website

Dr. rer. hum. Michel Grothe

Neuroimaging and Dementia research
German Center for Neurodegenerative Diseases (DZNE)
 

PD Dr. med. Tim Jürgens

Department of Neurology
University Medicine Rostock

Prof. Dr. med. Golo Kronenberg

Department of Psychiatry and Psychotherapy
University Medicine Rostock

Prof. Dr. med. Sönke Langner

Institute of Diagnostic and Interventional Radiology
University Medicine Rostock

Dr. phil. Corinna Lüthje

Institute for Media Research
Faculty of Philosophy
University of Rostock

 

Prof. Dr. med. Björn Spittau

Institute of Anatomy 
University Medicine Rostock

PD Dr. med. Kolja M. Thierfelder

Institute of Diagnostic and Interventional Radiology
University Medicine Rostock