Joint Research

Clinical Artificial Intelligence-based Diagnostics (CAIDX)

Project summary

Digitalisation is increasing rapidly across all sectors including healthcare. This can result in positive effects by increasing the healthcare sector's reactivity and resilience (increasing speed and accuracy of diagnostics, optimising resources).

AI and data driven diagnostics tools are being intensively developed for applications in the healthcare sector, but the uptake is difficult for several reasons:

  • Hospitals/clinicians see AI as a black box and do not understand the logic behind the algorithms used;
  • The industry does not necessarily grasp clinical needs, so they provide tools that are not meeting requirements of users;
  • Hospitals do not have the expertise to acquire and contract those tools based on validated scientific data;
  • Hospitals need support in developing tools together with solution providers and secure implementation into existing IT platforms, linking with patients’ data and fitting them in the workflow;
  • Staff is not prepared for adopting the solutions or trained to use and make the best use of them.

CAIDX aims to create the conditions to facilitate the uptake of AI and data driven diagnostics tools for healthcare (and hospitals in particular) by focusing on co-development, contracting, acquisition and capacity building. By developing standard procedures for development, testing and implementation of such AI applications, our solutions will improve and accompany the cultural change necessary to unfold the potential of AI in the healthcare sector.

Programme: Interreg Baltic Sea Region Programme 2021-2027

Implementation period: January 2023 – December 2025

Budget: 2.91€ Million in total 

Lead partner: The Innovation Clinic, Aalborg University Hospital, The North Denmark Region (DK)

Partners: 

  1. Wroclaw Technology Park (PL)
  2. BioCon Valley® GmbH (DE)
  3. Tartu BT Park OÜ (EE)
  4. Turku Science Park Ltd (FI)
  5. Lower Silesian Centre of Oncology, Pulmonology and Hematology (PL)
  6. Region Skane (SE)
  7. Innovation Skane (SE)
  8. Rostock University Medical Centre (DE)
  9. AUH Innovation, Aarhus University Hospital, Central Denmark Region (DK)
  10. Danish Life Science Cluster (DK)
  11. University of Rostock (DE)
  12. The Wellbeing Services County of Southwest Finland (FI)

https://interreg-baltic.eu/project/caidx/

PART: Patient Advisory Council for Participatory Research

The project "PART: Patient Advisory Council for Participatory Research" involves the active involvement of people with lived experience of a disease in the research process to improve quality, impact and relevance. This process is designed as a partnership between all stakeholders. Structures for active patient involvement in research will be created to assist in, for example, prioritizing research topics and objectives, creating information materials on research projects, recruiting patients, and interpreting and disseminating research results.

Institutes involved:

Clinic for Forensic Psychiatry, Rostock University Medical Center
Clinic and Polyclinic for Psychosomatic Medicine and Psychotherapy, Rostock University Medical Center, Section for Gerontopsychosomatics and Dementia
German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald

Funding body: Robert-Bosch-Stiftung

Funding duration: 2022 - 2025

More information about the project.

SASKit - Senescence-Associated Systems diagnostics Kit for cancer and stroke

With aging comes cellular senescence, and (multi-)morbidity. Cellular senescence is a key driver of an interconnected disease network including cancer and stroke. We wish to utilize systems modelling and bioinformatics, learning from omics and other lab data, to design and develop a biomarker and software kit with a focus on measuring and interpreting senescence related signatures for precise (and early) diagnosis, prognosis, and, ultimately, therapy, of pancreatic cancer and ischemic stroke/thromboembolism. We build upon publications describing how cellular senescence and the senescence-associated secretory phenotype are directly involved in the comorbidity of pancreatic cancer, ischemic stroke, and more generally, of cancer and coagulation problems. We propose observational human studies for pancreatic cancer and ischemic stroke, measuring senescence markers in particular, preparing the power analyses and the companion diagnostics for larger interventional trials. For pancreas, we propose co-culture studies of cancerous and stellate cells, and a mouse cancer allograft model. For stroke, we study brain slices and stroke recovery in mice. High-throughput gene expression and protein array data are taken from blood and tissue of mice, and from blood of human, to allow the bioinformatics to extrapolate protein expression and pathway activation for the inaccessible tissue of humans, providing optimized input to machine learning of the best sets of biomarkers.

PI University Medical Center Rostock: Prof. Dr. rer. nat. Georg Fuellen

Funding body: BMBF

More information about the project.

DigiCare - Digital Training of Nursing and Health Management

The goal of the overall project is the digitalisation of teaching in the field of nursing and health management. To achieve that, existing lectures will be recorded and organised in a semantic structure, so that at the end of the project, the lecture materials will interactively support both on-site lectures and distance learning. Furthermore, case-based dialogue system will be provided that will help the students to learn how to practically cope with different nursing cases.

PI University Medical Center Rostock: Prof. Dr. med. Stefan Teipel

Funding body: Eu­ro­pean So­cial Fund (ESF)

More information about the project.

SMARTGEM - Smartphone supported migraine therapy

The SMARTGEM project aims to enable effective, time-saving and cost-saving treatment of common migraine headaches: patients can use their smartphone app (M-sense) to document their headaches and identify potential triggering factors.

PI University Medical Center Rostock: PD Dr. med. Tim Jürgens

Funding body: Innovationsfonds des Gemeinsamen Bundesauschuss 

More information about the project.

AgeGain - Senior citizens train their mental fitness

In the study AgeGain, cognitively healthy older people complete four weeks of computer-based cognitive training. The dementia researchers under the direction of Prof. Stefan Teipel at the University Medical Centre Rostock measure the participants’ cognitive performance, brain structure and functioning as well as physical activity. AgeGain aims at identifying the neurobiological signs that predict if a person is able to transfer the improvement in trained exercises to other tasks that have not been practiced. This is essential, since cognitive training is ultimately intended to enhance cognitive functions needed for activities of daily living, in order to maintain independency and social participation in old age. In participatory workshops, the AgeGain participants additionally get the opportunity to actively analyse their own data.

The study is conducted in collaboration with three centres: the University Medical Center Mainz, the University Hospital Cologne and the German Sport University Cologne. AgeGain started in 2016. It is funded for a duration of four years by the German Federal Ministry of Education and Research (BMBF) (grant number: 01GQ1425A).

PI University Medical Center Rostock: Prof. Dr. med. Stefan Teipel

Cerebral FGF21-resistance as cause of the obesity-associated neurodegeneration

Metabolic syndrome, which includes visceral obesity, elevated triglycerides, elevated fasting blood sugar, high blood pressure and a decrease in HDL-cholesterol levels, comprises the most common chronic physical illness in modern society. Hypercholesterolemia may exert a negative effect on cognitive performance. One hormone, which regulates carbohydrate and lipid homeostasis and therefore the body weight, is the Fibroblast Growth Factor 21 (FGF21).  

 

PI University Medical Center Rostock: PD Dr. rer. nat. Angela Kuhla

 

Funding body: DFG

 

More information and contact.

AHeaD – Künftige Aufgabenteilung von Pflegefachpersonen und Hausärzten in der ambulanten Demenzversorgung: Aufgaben, Akzeptanz, Qualifikation

The AHeaD study investigates how the outpatient care of people with dementia can be shaped in the future with a changed division of labor between nurses and general practitioners and is accepted by the specialist groups as well as by those affected and their relatives.

PI University Medical Center Rostock: Prof. Dr. med. Attila Altiner

Funding body: Innovationsfonds des Gemeinsamen Bundesauschuss 

Funding duration: May 2017 - April 2020

CRC 1270 ELAINE: C03 Deep brain stimulation in dystonia models: Biological implementation, approximation of stimulation parameters and analysis of mechanisms

The aim of this project is to clarify the mechanisms of action of deep brain stimulation in dystonia, to define stimulation targets and stimulation paradigms, and to identify therapeutic success markers. We hypothesise that deep brain stimulation improves pathophysiological processes of dystonia, specifically synaptic / cellular plasticity, inhibitory tone and network oscillations via specific network changes, depending on target structure and stimulation parameters. We will therefore analyse the underlying mechanisms of deep brain stimulation, narrow down effective stimulation parameters, identify early biomarkers of therapeutic outcome, and analyse and model the effects of deep brain stimulation on the extended basal ganglia network.

PI University Medical Center Rostock: Prof. Dr. med. Rüdiger Köhling

More information and contact.

CRC 1270 ELAINE: C04 Effects of deep brain stimulation on adult neurogenesis in a rat model of Parkinson`s disease: Mechanisms of action, stimulation parameters and correlation with behaviour

Parkinson's disease is characterised by typical motor symptoms and various non-motor symptoms such as depression and dementia, which are conceivably related to defective neuronal plasticity. Although deep brain stimulation is meanwhile a routine procedure in advanced Parkinson's disease, the mechanisms behind its effects on non-motor symptoms remain elusive. We here propose to investigate the mechanisms of deep-brain stimulation related to the interplay between cellular brain plasticity and non-motor symptoms in a rat model for Parkinson's disease. The results will contribute not only to the understanding of actions of deep-brain stimulation, but also to knowledge of the pathophysiological mechanisms underlying depression and cognitive dysfunction.

PI University Medical Center Rostock: Prof. Dr. med. Alexander Storch

More information and contact.

PubMed publications between CTNR members from two and more different institutes (highlighted in bold, sorted by publication month). 

2024

Functional Outcomes in Conservatively vs Surgically Treated Cerebellar Infarcts.

Won SY, Hernández-Durán S, Behmanesh B, Bernstock JD, Czabanka M, Dinc N, Dubinski D, Freiman TM, Günther A, Hellmuth K, Herrmann E, Konczalla J, Maier I, Melkonian R, Mielke D, Naser P, Rohde V, Senft C, Storch A, Unterberg A, Walter J, Walter U, Wittstock M, Schaefer JH, Gessler F.JAMA Neurol. 2024 Feb 26;81(4):384-93. doi: 10.1001/jamaneurol.2023.5773. Online ahead of print.PMID: 38407889

2023

Cortical Amyloid Burden Relates to Basal Forebrain Volume in Subjective Cognitive Decline.

Daamen M, Scheef L, Li S, Grothe MJ, Gaertner FC, Buchert R, Buerger K, Dobisch L, Drzezga A, Essler M, Ewers M, Fliessbach K, Herrera Melendez AL, Hetzer S, Janowitz D, Kilimann I, Krause BJ, Lange C, Laske C, Munk MH, Peters O, Priller J, Ramirez A, Reimold M, Rominger A, Rostamzadeh A, Roeske S, Roy N, Scheffler K, Schneider A, Spottke A, Spruth EJ, Teipel SJ, Wagner M, Düzel E, Jessen F, Boecker H; DELCODE Study Group.J Alzheimers Dis. 2023;95(3):1013-1028. doi: 10.3233/JAD-230141.PMID: 37638433


Cerebellar Stroke Score and Grading Scale for the Prediction of Mortality and Outcomes in Ischemic Cerebellar Stroke.

Won SY, Melkonian R, Behmanesh B, Bernstock JD, Czabanka M, Dubinski D, Freiman TM, Günther A, Hellmuth K, Hernandez-Duran S, Herrmann E, Konczalla J, Maier I, Mielke D, Naser P, Rohde V, Schaefer JH, Senft C, Storch A, Trnovec S, Unterberg A, Walter J, Walter U, Wittstock M, Dinc N, Gessler F.Stroke. 2023 Oct;54(10):2569-2575. doi: 10.1161/STROKEAHA.123.043478. Epub 2023 Aug 8.PMID: 37551591


Necrosectomy Versus Stand-Alone Suboccipital Decompressive Craniectomy for the Management of Space-Occupying Cerebellar Infarctions-A Retrospective Multicenter Study.

Hernandez-Duran S, Walter J, Behmanesh B, Bernstock JD, Czabanka M, Dinc N, Dubinski D, Freiman TM, Günther A, Hellmuth K, Herrmann E, Konczalla J, Maier I, Melkonian R, Mielke D, Müller SJ, Naser P, Rohde V, Schaefer JH, Senft C, Storch A, Unterberg A, Walter U, Wittstock M, Gessler F, Won SY.Neurosurgery. 2023 Oct 6. doi: 10.1227/neu.0000000000002707. Online ahead of print.PMID: 37800900


CCR2 macrophage response determines the functional outcome following cardiomyocyte transplantation.

Vasudevan P, Wolfien M, Lemcke H, Lang CI, Skorska A, Gaebel R, Galow AM, Koczan D, Lindner T, Bergmann W, Mueller-Hilke B, Vollmar B, Krause BJ, Wolkenhauer O, Steinhoff G, David R.Genome Med. 2023 Aug 10;15(1):61. doi: 10.1186/s13073-023-01213-3.PMID: 37563727


Patient-related benefits of amyloid PET imaging in dementia: Rationale and design of the German randomized coverage with evidence development study ENABLE.

Teipel SJ, Spottke A, Boecker H, Daamen M, Graf E, Sahlmann J, Buchert R, Mohnike W, Mohnike K, Kurth J, Jessen F, Krause BJ.Alzheimers Dement (N Y). 2023 Aug 8;9(3):e12383. doi: 10.1002/trc2.12383. eCollection 2023 Jul-Sep.PMID: 37560401


Structural and molecular cholinergic imaging markers of cognitive decline in Parkinson's disease.

Schumacher J, Kanel P, Dyrba M, Storch A, Bohnen NI, Teipel S, Grothe MJ.Brain. 2023 Jul 5:awad226. doi: 10.1093/brain/awad226. Online ahead of print.PMID: 37403733


Protein Biomarkers in Blood Reflect the Interrelationships Between Stroke Outcome, Inflammation, Coagulation, Adhesion, Senescence and Cancer.

Fuellen GWalter U, Henze L, Böhmert J, Palmer D, Lee S, Schmitt CA, Rudolf H, Kowald A.Cell Mol Neurobiol. 2023 May;43(4):1413-1424. doi: 10.1007/s10571-022-01260-1. Epub 2022 Aug 11.PMID: 35953740


Live Cell Imaging of ATP Levels Reveals Metabolic Compartmentalization within Motoneurons and Early Metabolic Changes in FUS ALS Motoneurons.

Zimyanin VL, Pielka AM, Glaß H, Japtok J, Großmann D, Martin M, Deussen A, Szewczyk B, Deppmann C, Zunder E, Andersen PM, Boeckers TM, Sterneckert J, Redemann S, Storch A, Hermann A.Cells. 2023 May 9;12(10):1352. doi: 10.3390/cells12101352.PMID: 37408187 


Notch is Not Involved in Physioxia-Mediated Stem Cell Maintenance in Midbrain Neural Stem Cells.

Herrmann A, Meyer AK, Braunschweig L, Wagenfuehr L, Markert F, Kolitsch D, Vukicevic V, Hartmann C, Siebert M, Ehrhart-Bornstein M, Hermann A, Storch A.Int J Stem Cells. 2023 Aug 30;16(3):293-303. doi: 10.15283/ijsc22168. Epub 2023 Apr 30.PMID: 37105558


Uncoupling protein 2 deficiency of non-cancerous tissues inhibits the progression of pancreatic cancer in mice.

Revskij D, Runst J, Umstätter C, Ehlers L, Rohde S, Zechner D, Bastian M, Müller-Hilke B, Fuellen G, Henze L, Murua Escobar H, Junghanss C, Kowald A, Walter U, Köhling R, Wolkenhauer O, Jaster R.Hepatobiliary Pancreat Dis Int. 2023 Apr;22(2):190-199. doi: 10.1016/j.hbpd.2022.12.003. Epub 2022 Dec 14.PMID: 36549966


Headache impact and socioeconomic status: findings from a study of the German Migraine and Headache Society (DMKG).

Müller B, Gaul C, Reis O, Jürgens TP, Kropp P, Ruscheweyh R, Straube A, Brähler E, Förderreuther S, Schroth J, Dresler T.J Headache Pain. 2023 Apr 4;24(1):37. doi: 10.1186/s10194-023-01564-7.PMID: 37016306 


[18F]GE-180-PET and Post Mortem Marker Characteristics of Long-Term High-Fat-Diet-Induced Chronic Neuroinflammation in Mice.

Müller L, Power Guerra N, Schildt A, Lindner T, Stenzel J, Behrangi N, Bergner C, Alberts T, Bühler D, Kurth J, Krause BJ, Janowitz D, Teipel S, Vollmar BKuhla A.Biomolecules. 2023 Apr 28;13(5):769. doi: 10.3390/biom13050769.PMID: 37238638


Leptin deficiency-caused behavioral change - A comparative analysis using EthoVision and DeepLabCut.

Bühler D, Power Guerra N, Müller L, Wolkenhauer O, Düffer M, Vollmar BKuhla A, Wolfien M.Front Neurosci. 2023 Mar 24;17:1052079. doi: 10.3389/fnins.2023.1052079. eCollection 2023.PMID: 37034162 


Systematic estimation of biological age of in vitro cell culture systems by an age-associated marker panel.

Hartmann C, Herling L, Hartmann A, Köckritz V, Fuellen G, Walter M, Hermann A.Front Aging. 2023 Feb 15;4:1129107. doi: 10.3389/fragi.2023.1129107. eCollection 2023.PMID: 36873743 


The Dorsal Skinfold Chamber as a New Tympanic Membrane Wound Healing Model: Intravital Insights into the Pathophysiology of Epithelialized Wounds.

Strüder D, Lachmann C, van Bonn SM, Grambow E, Schraven SP, Mlynski RVollmar B.Eur Surg Res. 2023;64(2):286-300. doi: 10.1159/000519774. Epub 2021 Dec 2.PMID: 34856545 


At Crossroads in a Virtual City: Effect of Spatial Disorientation on Gait Variability and Psychophysiological Response among Healthy Older Adults.

Amaefule CO, Lüdtke S, Klostermann A, Hinz CA, Kampa I, Kirste TTeipel S.Gerontology. 2023;69(4):450-463. doi: 10.1159/000527503. Epub 2022 Dec 5.PMID: 36470232

2022

At Crossroads in a Virtual City: Effect of Spatial Disorientation on Gait Variability and Psychophysiological Response among Healthy Older Adults.

Amaefule CO, Lüdtke S, Klostermann A, Hinz CA, Kampa I, Kirste TTeipel S.Gerontology. 2022 Dec 5:1-14. doi: 10.1159/000527503. Online ahead of print.PMID: 36470232 


Effects of Microbeam Irradiation on Rodent Esophageal Smooth Muscle Contraction.

Frerker B, Fiedler S, Kirschstein T, Lange F, Porath K, Sellmann T, Kutzner L, Wilde F, Moosmann J, Köhling R, Hildebrandt G, Schültke E.Cells. 2022 Dec 31;12(1):176. doi: 10.3390/cells12010176.PMID: 36611969 


Abnormal Pre-mRNA Splicing in Exonic Fabry Disease-Causing GLA Mutations.

Alfen F, Putscher E, Hecker M, Zettl UK, Hermann A, Lukas J.Int J Mol Sci. 2022 Dec 3;23(23):15261. doi: 10.3390/ijms232315261.PMID: 36499585 


Headache in Multiple Sclerosis - Pharmacological Aspects.

Gebhardt M, Kropp P, Hoffmann F, Zettl UK.Curr Pharm Des. 2022;28(6):445-453. doi: 10.2174/1381612827666210922114100.PMID: 34551691


Uncoupling protein 2 deficiency of non-cancerous tissues inhibits the progression of pancreatic cancer in mice.

Revskij D, Runst J, Umstätter C, Ehlers L, Rohde S, Zechner D, Bastian M, Müller-Hilke B, Fuellen G, Henze L, Murua Escobar H, Junghanss C, Kowald A, Walter U, Köhling R, Wolkenhauer O, Jaster R.Hepatobiliary Pancreat Dis Int. 2022 Dec 14:S1499-3872(22)00281-8. doi: 10.1016/j.hbpd.2022.12.003. Online ahead of print.PMID: 36549966


Organ Weights in NPC1 Mutant Mice Partly Normalized by Various Pharmacological Treatment Approaches.

Antipova V, Steinhoff LM, Holzmann C, Rolfs A, Hempel CJ, Witt MWree A.Int J Mol Sci. 2022 Dec 29;24(1):573. doi: 10.3390/ijms24010573.PMID: 36614015 


Commentary: Acanthocytes identified in Huntington's disease.

Peikert K, Storch A, Hermann A, Landwehrmeyer GB, Walker RH, Simionato G, Kaestner L, Danek A.Front Neurosci. 2022 Nov 4;16:1049676. doi: 10.3389/fnins.2022.1049676. eCollection 2022.PMID: 36408380


Siponimod ameliorates metabolic oligodendrocyte injury via the sphingosine-1 phosphate receptor 5.

Behrangi N, Heinig L, Frintrop L, Santrau E, Kurth J, Krause B, Atanasova D, Clarner T, Fragoulis A, Joksch M, Rudolf H, Meuth SG, Joost S, Kipp M. Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2204509119. doi: 10.1073/pnas.2204509119. Epub 2022 Sep 26. PMID: 36161894


Melanoma 2.0. Skin cancer as a paradigm for emerging diagnostic technologies, computational modelling and artificial intelligence.

Vera J, Lai X, Baur A, Erdmann M, Gupta S, Guttà C, Heinzerling L, Heppt MV, Kazmierczak PM, Kunz M, Lischer C, Pützer BM, Rehm M, Ostalecki C, Retzlaff J, Witt S, Wolkenhauer O, Berking C. Brief Bioinform. 2022 Oct 17:bbac433. doi: 10.1093/bib/bbac433. Online ahead of print. PMID: 36252807


[Parental Stress: Psychometric Evaluation of the German Version of the Parental Stress Scale in the General Population].

Kölch M, Lübke L, Müller S, Reis O, Brähler E, Lincke L, Spitzer C.Psychother Psychosom Med Psychol. 2022 Oct;72(9-10):445-451. doi: 10.1055/a-1778-5316. Epub 2022 Mar 14.PMID: 35287236 


Evaluation of the Synergistic Potential of Simultaneous Pan- or Isoform-Specific BET and SYK Inhibition in B-Cell Lymphoma: An In Vitro Approach.

Sender S, Sultan AW, Palmer D, Koczan D, Sekora A, Beck J, Schuetz E, Taher L, Brenig B, Fuellen G, Junghanss C, Murua Escobar H. Cancers (Basel). 2022 Sep 27;14(19):4691. doi: 10.3390/cancers14194691. PMID: 36230614


Cognitive and behavioural but not motor impairment increases brain age in amyotrophic lateral sclerosis.

Hermann A, Tarakdjian GN, Temp AGM, Kasper E, Machts J, Kaufmann J, Vielhaber S, Prudlo J, Cole JH, Teipel S, Dyrba M.Brain Commun. 2022 Sep 22;4(5):fcac239. doi: 10.1093/braincomms/fcac239. eCollection 2022.PMID: 36246047


Microbeam Irradiation of the Beating Rodent Heart: An Ex Vivo Study of Acute and Subacute Effects on Cardiac Function.

Lange F, Kirschstein T, Davis J, Paino J, Barnes M, Klein M, Porath K, Stöhlmacher P, Fiedler S, Frank M, Köhling R, Hildebrandt G, Hausermann D, Lerch M, Schültke E.Int J Radiat Oncol Biol Phys. 2022 Sep 1;114(1):143-152. doi: 10.1016/j.ijrobp.2022.05.001. Epub 2022 May 6.PMID: 35533907


A conserved long-distance telomeric silencing mechanism suppresses mTOR signaling in aging human fibroblasts.

Jäger K, Mensch J, Grimmig ME, Neuner B, Gorzelniak K, Türkmen S, Demuth I, Hartmann A, Hartmann C, Wittig F, Sporbert A, Hermann A, Fuellen G, Möller S, Walter M. Sci Adv. 2022 Aug 19;8(33):eabk2814. doi: 10.1126/sciadv.abk2814. Epub 2022 Aug 17. PMID: 35977016


Protein Biomarkers in Blood Reflect the Interrelationships Between Stroke Outcome, Inflammation, Coagulation, Adhesion, Senescence and Cancer.

Fuellen G, Walter U, Henze L, Böhmert J, Palmer D, Lee S, Schmitt CA, Rudolf H, Kowald A. Cell Mol Neurobiol. 2022 Aug 11:1-12. doi: 10.1007/s10571-022-01260-1. Online ahead of print. PMID: 35953740


Spontaneous Hind Limb Paralysis Due to Acute Precursor B Cell Leukemia in RAG1-deficient Mice.

Feifei L, Richter A, Runge J, Keiler J, Hermann A, Kipp M, Joost S. J Mol Neurosci. 2022 Aug;72(8):1646-1655. doi: 10.1007/s12031-022-02025-7. Epub 2022 May 18. PMID: 35583713


Cognitive reserve protects ALS-typical cognitive domains: A longitudinal study.

Temp AGM, Kasper E, Machts J, Vielhaber S, Teipel S, Hermann A, Prudlo J. Ann Clin Transl Neurol. 2022 Aug;9(8):1212-1223. doi: 10.1002/acn3.51623. Epub 2022 Jul 22. PMID: 35866289


[Assessment of General Family Functioning: Psychometric Evaluation of the German Version of the Brief Assessment of Family Functioning Scale].

Spitzer C, Lübke L, Göbel P, Müller S, Krogmann D, Brähler E, Reis O, Lincke L, Kölch M.Psychother Psychosom Med Psychol. 2022 Jul;72(7):292-298. doi: 10.1055/a-1692-8763. Epub 2021 Dec 15.PMID: 34911106 


Modification of the Langendorff system of the isolated beating heart for experimental radiotherapy at a synchrotron: 4000 Gy in a heart beat.

Schültke E, Lerch M, Kirschstein T, Lange F, Porath K, Fiedler S, Davis J, Paino J, Engels E, Barnes M, Klein M, Hall C, Häusermann D, Hildebrandt G.J Synchrotron Radiat. 2022 Jul 1;29(Pt 4):1027-1032. doi: 10.1107/S1600577522004489. Epub 2022 May 18.PMID: 35787570


Differential Cellular Balance of Olfactory and Vomeronasal Epithelia in a Transgenic BACHD Rat Model of Huntington's Disease.

Krysewski LM, Power Guerra N, Glatzel A, Holzmann C, Antipova V, Schmitt O, Yu-Taeger L, Nguyen HP, Wree A, Witt M. Int J Mol Sci. 2022 Jul 10;23(14):7625. doi: 10.3390/ijms23147625. PMID: 35886975


Molecular Characterization of the Response to Conventional Chemotherapeutics in Pro-B-ALL Cell Lines in Terms of Tumor Relapse.

Gladbach YS, Sklarz LM, Roolf C, Beck J, Schütz E, Fuellen G, Junghanss C, Murua Escobar H, Hamed M. Genes (Basel). 2022 Jul 14;13(7):1240. doi: 10.3390/genes13071240. PMID: 35886023


[Assessment of General Family Functioning: Psychometric Evaluation of the German Version of the Brief Assessment of Family Functioning Scale].

Spitzer C, Lübke L, Göbel P, Müller S, Krogmann D, Brähler E, Reis O, Lincke L, Kölch M. Psychother Psychosom Med Psychol. 2022 Jul;72(7):292-298. doi: 10.1055/a-1692-8763. Epub 2021 Dec 15. PMID: 34911106


Physical Activity is Associated with Less Analgesic Use in Women Reporting Headache-A Cross-Sectional Study of the German Migraine and Headache Society (DMKG).

Müller B, Gaul C, Glass Ä, Reis O, Jürgens TP, Kropp P, Ruscheweyh R, Straube A, Brähler E, Förderreuther S, Dresler T. Pain Ther. 2022 Jun;11(2):545-560. doi: 10.1007/s40122-022-00362-4. Epub 2022 Feb 25. PMID: 35212968


Early Post-ischemic Brain Glucose Metabolism Is Dependent on Function of TLR2: a Study Using [18F]F-FDG PET-CT in a Mouse Model of Cardiac Arrest and Cardiopulmonary Resuscitation.

Bajorat R, Kurth J, Stenzel J, Vollmar B, Krause BJ, Reuter DA, Schuerholz T, Bergt S. Mol Imaging Biol. 2022 Jun;24(3):466-478. doi: 10.1007/s11307-021-01677-y. Epub 2021 Nov 15. PMID: 34779968


Cerebral venous sinus thrombosis after adenovirus-vectored COVID-19 vaccination: review of the neurological-neuroradiological procedure.

Wittstock M, Walter U, Volmer E, Storch A, Weber MA, Großmann A. Neuroradiology. 2022 May;64(5):865-874. doi: 10.1007/s00234-022-02914-z. Epub 2022 Feb 19. PMID: 35184205.


Lethal form of a late-onset aquaporin-4 antibody-positive NMOSD related to the immune checkpoint inhibitor nivolumab.

Weiss D, Cantré D, Zettl UK, Storch A, Prudlo J. J Neurol. 2022 May;269(5):2778-2780. doi: 10.1007/s00415-021-10913-y. Epub 2021 Nov 28. PMID: 34841443


Prediction of Disorientation by Accelerometric and Gait Features in Young and Older Adults Navigating in a Virtually Enriched Environment.

Teipel SJ, Amaefule CO, Lüdtke S, Görß D, Faraza S, Bruhn S, Kirste T. Front Psychol. 2022 Apr 25;13:882446. doi: 10.3389/fpsyg.2022.882446. eCollection 2022. PMID: 35548510


Dentate-nucleus gadolinium deposition on magnetic resonance imaging: ultrasonographic and clinical correlates in multiple sclerosis patients.

Kühn I, Maschke H, Großmann A, Hauenstein K, Weber MA, Zettl UK, Storch A, Walter U. Neurol Sci. 2022 Apr;43(4):2631-2639. doi: 10.1007/s10072-021-05702-4. Epub 2021 Nov 4. PMID: 34735650


Targeting pancreatic cancer with combinatorial treatment of CPI-613 and inhibitors of lactate metabolism.

Kumstel S, Schreiber T, Goldstein L, Stenzel J, Lindner T, Joksch M, Zhang X, Wendt EHU, Schönrogge M, Krause B, Vollmar B, Zechner D. PLoS One. 2022 Apr 22;17(4):e0266601. doi: 10.1371/journal.pone.0266601. eCollection 2022. PMID: 35452495


Headache in the Neurological Emergency Department-High Degree of Inadequate Documentation Calls for Structured Assessments.

Rimmele F, Janke J, Kropp P, Kasch R, Walter U, Jürgens TP. Front Neurol. 2022 Mar 24;13:847484. doi: 10.3389/fneur.2022.847484. eCollection 2022. PMID: 35401419


[Parental Stress: Psychometric Evaluation of the German Version of the Parental Stress Scale in the General Population].

Kölch M, Lübke L, Müller S, Reis O, Brähler E, Lincke L, Spitzer C. Psychother Psychosom Med Psychol. 2022 Mar 14. doi: 10.1055/a-1778-5316. Online ahead of print. PMID: 35287236


Affection of Respiratory Muscles in ALS and SMA.

Hermann W, Langner S, Freigang M, Fischer S, Storch A, Günther R, Hermann A. J Clin Med. 2022 Feb 22;11(5):1163. doi: 10.3390/jcm11051163. PMID: 35268254


Motor-Independent Cognitive Testing in Motor Degenerative Diseases.

Schmitz-Peiffer H, Aust E, Linse K, Rueger W, Joos M, Löhle M, Storch A, Hermann A. J Clin Med. 2022 Feb 3;11(3):814. doi: 10.3390/jcm11030814. PMID: 35160265


CT imaging-based approaches to cochlear duct length estimation-a human temporal bone study.

Breitsprecher T, Dhanasingh A, Schulze M, Kipp M, Dakah RA, Oberhoffner T, Dau M, Frerich B, Weber MA, Langner S, Mlynski R, Weiss NM. Eur Radiol. 2022 Feb;32(2):1014-1023. doi: 10.1007/s00330-021-08189-x. Epub 2021 Aug 31. PMID: 34463797


Functional MAOB Gene Intron 13 Polymorphism Predicts Dyskinesia in Parkinson's Disease.

Löhle M, Mangone G, Hermann W, Hausbrand D, Wolz M, Mende J, Reichmann H, Hermann A, Corvol JC, Storch A. Parkinsons Dis. 2022 Jan 20;2022:5597503. doi: 10.1155/2022/5597503. eCollection 2022. PMID: 35096365


Loss of "insight" into behavioral changes in ALS: Differences across cognitive profiles.

Temp AGM, Kasper E, Vielhaber S, Machts J, Hermann A, Teipel S, Prudlo J. Brain Behav. 2022 Jan;12(1):e2439. doi: 10.1002/brb3.2439. Epub 2021 Dec 2. PMID: 34855301


The Prognostic and Predictive Role of Xeroderma Pigmentosum Gene Expression in Melanoma.

Fischer S, Hamed M, Emmert S, Wolkenhauer O, Fuellen G, Thiem A. Front Oncol. 2022 Jan 31;12:810058. doi: 10.3389/fonc.2022.810058. eCollection 2022. PMID: 35174087


Olfactory Bulb D2/D3 Receptor Availability after Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson's Disease.

Alberts T, Antipova V, Holzmann C, Hawlitschka A, Schmitt O, Kurth J, Stenzel J, Lindner T, Krause BJ, Wree A, Witt M. Toxins (Basel). 2022 Jan 25;14(2):94. doi: 10.3390/toxins14020094. PMID: 35202123


The Molecular Subtype of Adult Acute Lymphoblastic Leukemia Samples Determines the Engraftment Site and Proliferation Kinetics in Patient-Derived Xenograft Models.

Richter A, Roolf C, Sekora A, Knuebel G, Krohn S, Lange S, Krebs V, Schneider B, Lakner J, Wittke C, Kiefel C, Jeremias I, Murua Escobar H, Vollmar B, Junghanss C. Cells. 2022 Jan 3;11(1):150. doi: 10.3390/cells11010150. PMID: 35011712 Free PMC article.


Establishment and Characterization of FusionRed Stable Transfected Canine Prostate Adenocarcinoma and Transitional Cell Carcinoma Cells.

Alnajjar S, Nolte I, Schille JT, Sender S, Trakoolju N, Perez SV, Zechner D, Vollmar B, Junghanss C, Murua Escobar H. In Vivo. 2022 Jan-Feb;36(1):170-179. doi: 10.21873/invivo.12688. PMID: 34972712

2021

The Dorsal Skinfold Chamber as a New Tympanic Membrane Wound Healing Model: Intravital Insights into the Pathophysiology of Epithelialized Wounds.

Strüder D, Lachmann C, van Bonn SM, Grambow E, Schraven SP, Mlynski RVollmar B.Eur Surg Res. 2021 Dec 2;63(4):1-15. doi: 10.1159/000519774. Online ahead of print.PMID: 34856545


Neuronal Hyperexcitability in APPSWE/PS1dE9 Mouse Models of Alzheimer's Disease.

Müller L, Kirschstein T, Köhling RKuhla A, Teipel S.J Alzheimers Dis. 2021;81(3):855-869. doi: 10.3233/JAD-201540.PMID: 33843674


Neuroprotective Effects of the FGF21 Analogue LY2405319.

Rühlmann C, Dannehl D, Brodtrück M, Adams AC, Stenzel J, Lindner T, Krause BJ, Vollmar B, Kuhla A.J Alzheimers Dis. 2021;80(1):357-369. doi: 10.3233/JAD-200837.PMID: 33554901


Adult Neural Stem Cells from Midbrain Periventricular Regions Show Limited Neurogenic Potential after Transplantation into the Hippocampal Neurogenic Niche.

Fauser M, Loewenbrück KF, Rangnick J, Brandt MD, Hermann A, Storch A.Cells. 2021 Nov 4;10(11):3021. doi: 10.3390/cells10113021.PMID: 34831242


[Cerebral venous sinus thrombosis after COVID-19 vaccination : Neurological and radiological management].

Walter U, Volmer E, Wittstock M, Storch AWeber MA, Großmann A.Radiologe. 2021 Oct;61(10):923-932. doi: 10.1007/s00117-021-00887-3. Epub 2021 Jul 29.PMID: 34327553


The software defined implantable modular platform (STELLA) for preclinical deep brain stimulation research in rodents.

Plocksties F, Kober M, Niemann C, Heller J, Fauser M, Nüssel M, Uster F, Franz D, Zwar M, Lüttig A, Kröger J, Harloff J, Schulz A, Richter A, Köhling R, Timmermann D, Storch A.J Neural Eng. 2021 Sep 21;18(5). doi: 10.1088/1741-2552/ac23e1.PMID: 34542029


Headache Characteristics in the Neurological Emergency Department: A Retrospective Study.

Rimmele F, Janke J, Kropp P, Grossmann A, Hamann T, Walter U, Jürgens TP.Front Neurol. 2021 Aug 19;12:706074. doi: 10.3389/fneur.2021.706074. eCollection 2021.PMID: 34489852


Establishment and characterization of patient-derived head and neck cancer models from surgical specimens and endoscopic biopsies.

Strüder D, Momper T, Irmscher N, Krause M, Liese J, Schraven S, Zimpfer A, Zonnur S, Burmeister AS, Schneider B, Frerich B, Mlynski R, Große-Thie C, Junghanss C, Maletzki C.J Exp Clin Cancer Res. 2021 Aug 6;40(1):246. doi: 10.1186/s13046-021-02047-w.PMID: 34362423


Fibroblast Growth Factor 21 as a Potential Biomarker for Improved Locomotion and Olfaction Detection Ability after Weight Reduction in Obese Mice.

Power Guerra N, Parveen A, Bühler D, Brauer DL, Müller L, Pilz K, Witt M, Glass Ä, Bajorat R, Janowitz D, Wolkenhauer O, Vollmar BKuhla A.Nutrients. 2021 Aug 24;13(9):2916. doi: 10.3390/nu13092916.PMID: 34578793


Interleukin-17 and Th17 Lymphocytes Directly Impair Motoneuron Survival of Wildtype and FUS-ALS Mutant Human iPSCs.

Jin M, Akgün K, Ziemssen T, Kipp M, Günther R, Hermann A.Int J Mol Sci. 2021 Jul 27;22(15):8042. doi: 10.3390/ijms22158042.PMID: 34360808 


Antidepressant-Like Properties of Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson's Disease.

Antipova V, Holzmann C, Hawlitschka A, Witt MWree A.Toxins (Basel). 2021 Jul 20;13(7):505. doi: 10.3390/toxins13070505.PMID: 34357977


Cognitive reserve and regional brain volume in amyotrophic lateral sclerosis.

Temp AGM, Prudlo J, Vielhaber S, Machts J, Hermann ATeipel SJ, Kasper E.Cortex. 2021 Jun;139:240-248. doi: 10.1016/j.cortex.2021.03.005. Epub 2021 Mar 17.PMID: 33892294 Free


Simultaneous Assessment of Electroencephalography Microstates and Resting State Intrinsic Networks in Alzheimer's Disease and Healthy Aging.

Teipel SJ, Brüggen K, Temp AGM, Jakobi K, Weber MA, Berger C.Front Neurol. 2021 Jun 17;12:637542. doi: 10.3389/fneur.2021.637542. eCollection 2021.PMID: 34220668


Expedient assessment of post-infarct remodeling by native cardiac magnetic resonance imaging in mice.

Lang CI, Vasudevan P, Döring P, Gäbel R, Lemcke H, Lindner T, Steinhoff G, Krause BJVollmar B, Meinel FG, Yücel S, Öner A, Ince H, David R.Sci Rep. 2021 Jun 2;11(1):11625. doi: 10.1038/s41598-021-91096-4.PMID: 34079005 


Evaluation of Choroidal Melanoma Vascularization by Color Doppler Flow Imaging: An Option for Follow-Up Tumor Control Assessment after CyberKnife®?

Kaak C, Kakkassery V, Scheef BO, Zschoche M, Rommel F, Hildebrandt G, Emmert S, Junghanß C, Guthoff RF, Jünemann AM, Walter U.Medicina (Kaunas). 2021 May 31;57(6):553. doi: 10.3390/medicina57060553.PMID: 34072742


Multimodal Imaging Techniques to Evaluate the Anticancer Effect of Cold Atmospheric Pressure Plasma.

Kordt M, Trautmann I, Schlie C, Lindner T, Stenzel J, Schildt A, Boeckmann L, Bekeschus S, Kurth J, Krause BJVollmar B, Grambow E.Cancers (Basel). 2021 May 19;13(10):2483. doi: 10.3390/cancers13102483.PMID: 34069689 


Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring.

Hartmann A, Hartmann C, Secci R, Hermann AFuellen G,Walter M.Front Genet. 2021 May 21;12:686320. doi: 10.3389/fgene.2021.686320. eCollection 2021.PMID: 34093670 


One nerve suffices: A clinically guided nerve ultrasound protocol for the differentiation of multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis (ALS).

Loewenbrück KF, Werner R, Günther R, Dittrich M, Klingenberger R, Reichmann H, Storch A, Hermann A.J Neurol. 2021 Apr;268(4):1495-1507. doi: 10.1007/s00415-020-10323-6. Epub 2020 Dec 23.PMID: 33355881


Chronic-Progressive Dopaminergic Deficiency Does Not Induce Midbrain Neurogenesis.

Fauser M, Pan-Montojo F, Richter C, Kahle PJ, Schwarz SC, Schwarz J, Storch A, Hermann A.Cells. 2021 Mar 31;10(4):775. doi: 10.3390/cells10040775.PMID: 33807497


Longitudinal observation of anxiety and depression among palliative care cancer patients.

Sewtz C, Muscheites W, Grosse-Thie C, Kriesen U, Leithaeuser M, Glaeser D, Hansen P, Kundt G, Fuellen G, Junghanss C.Ann Palliat Med. 2021 Apr;10(4):3836-3846. doi: 10.21037/apm-20-1346. Epub 2021 Mar 22.PMID: 33832298 


Long-Term Caloric Restriction Attenuates β-Amyloid Neuropathology and Is Accompanied by Autophagy in APPswe/PS1delta9 Mice.

Müller L, Power Guerra N, Stenzel J, Rühlmann C, Lindner T, Krause BJ, Vollmar B, Teipel SKuhla A.Nutrients. 2021 Mar 18;13(3):985. doi: 10.3390/nu13030985.PMID: 33803798


Gender-Specific Effects of Two Treatment Strategies in a Mouse Model of Niemann-Pick Disease Type C1.

Holzmann C, Witt M, Rolfs A, Antipova V, Wree A.Int J Mol Sci. 2021 Mar 3;22(5):2539. doi: 10.3390/ijms22052539.PMID: 33802605 


[Coping in families with members suffering from a mental disorder].

Reis O, Steigmiller L, Spitzer CKölch M, Knabe A.Psychotherapeut (Berl). 2021;66(3):217-224. doi: 10.1007/s00278-021-00492-8. Epub 2021 Feb 9.PMID: 33584012 


[Consequences of the corona pandemic on social networks in families at risk].

Knabe A, Kölch M, Spitzer C, Reis O.Psychotherapeut (Berl). 2021;66(3):225-232. doi: 10.1007/s00278-021-00491-9. Epub 2021 Feb 10.PMID: 33584013 


68 Ga-Labelled Tropane Analogues for the Visualization of the Dopaminergic System.

Häseli S, Holy M, Joksch M, Bergner C, Wree A, Kurth J, Cankaya A, Piel M, Krause BJ, Sitte HH, Rösch F.ChemMedChem. 2021 Mar 3;16(5):804-808. doi: 10.1002/cmdc.202000820. Epub 2020 Dec 10.PMID: 33245194


Correlation between Kir4.1 expression and barium-sensitive currents in rat and human glioma cell lines.

Madadi A, Wolfart J, Lange F, Brehme H, Linnebacher M, Bräuer AU, Büttner A, Freiman T, Henker C, Einsle A, Rackow S, Köhling R, Kirschstein T, Müller S.Neurosci Lett. 2021 Jan 10;741:135481. doi: 10.1016/j.neulet.2020.135481. Epub 2020 Nov 5.PMID: 33161102


[LATE: not every dementia is Alzheimer's disease-Discussion of a new disease entity based on a case example : Current status of limbic-predominant age-related TDP-43 encephalopathy (LATE)].

Görß D, Kilimann I, Dyrba M, Nitsch S, Krause B, Teipel S.Nervenarzt. 2021 Jan;92(1):18-26. doi: 10.1007/s00115-020-00922-z.PMID: 32409844 


An algorithm for actigraphy-based sleep/wake scoring: Comparison with polysomnography.

Lüdtke S, Hermann W, Kirste T, Beneš H, Teipel S.Clin Neurophysiol. 2021 Jan;132(1):137-145. doi: 10.1016/j.clinph.2020.10.019. Epub 2020 Nov 13.PMID: 33278666


Abnormal Regional and Global Connectivity Measures in Subjective Cognitive Decline Depending on Cerebral Amyloid Status.

Li S, Daamen M, Scheef L, Gaertner FC, Buchert R, Buchmann M, Buerger K, Catak C, Dobisch L, Drzezga A, Ertl-Wagner B, Essler M, Fliessbach K, Haynes JD, Incesoy EI, Kilimann I, Krause BJ, Lange C, Laske C, Priller J, Ramirez A, Reimold M, Rominger A, Roy N, Scheffler K, Maurer A, Schneider A, Spottke A, Spruth EJ, Teipel SJ, Tscheuschler M, Wagner M, Wolfsgruber S, Düzel E, Jessen F, Peters O, Boecker H; DELCODE Study Group.J Alzheimers Dis. 2021;79(2):493-509. doi: 10.3233/JAD-200472.PMID: 33337359

Research Environment