Joint Research

PART: Patient Advisory Council for Participatory Research

The project "PART: Patient Advisory Council for Participatory Research" involves the active involvement of people with lived experience of a disease in the research process to improve quality, impact and relevance. This process is designed as a partnership between all stakeholders. Structures for active patient involvement in research will be created to assist in, for example, prioritizing research topics and objectives, creating information materials on research projects, recruiting patients, and interpreting and disseminating research results.

Institutes involved:

Clinic for Forensic Psychiatry, Rostock University Medical Center
Clinic and Polyclinic for Psychosomatic Medicine and Psychotherapy, Rostock University Medical Center, Section for Gerontopsychosomatics and Dementia
German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald

Funding body: Robert-Bosch-Stiftung

Funding duration: 2022 - 2025

More information about the project.

SASKit - Senescence-Associated Systems diagnostics Kit for cancer and stroke

With aging comes cellular senescence, and (multi-)morbidity. Cellular senescence is a key driver of an interconnected disease network including cancer and stroke. We wish to utilize systems modelling and bioinformatics, learning from omics and other lab data, to design and develop a biomarker and software kit with a focus on measuring and interpreting senescence related signatures for precise (and early) diagnosis, prognosis, and, ultimately, therapy, of pancreatic cancer and ischemic stroke/thromboembolism. We build upon publications describing how cellular senescence and the senescence-associated secretory phenotype are directly involved in the comorbidity of pancreatic cancer, ischemic stroke, and more generally, of cancer and coagulation problems. We propose observational human studies for pancreatic cancer and ischemic stroke, measuring senescence markers in particular, preparing the power analyses and the companion diagnostics for larger interventional trials. For pancreas, we propose co-culture studies of cancerous and stellate cells, and a mouse cancer allograft model. For stroke, we study brain slices and stroke recovery in mice. High-throughput gene expression and protein array data are taken from blood and tissue of mice, and from blood of human, to allow the bioinformatics to extrapolate protein expression and pathway activation for the inaccessible tissue of humans, providing optimized input to machine learning of the best sets of biomarkers.

PI University Medical Center Rostock: Prof. Dr. rer. nat. Georg Fuellen

Funding body: BMBF

More information about the project.

DigiCare - Digital Training of Nursing and Health Management

The goal of the overall project is the digitalisation of teaching in the field of nursing and health management. To achieve that, existing lectures will be recorded and organised in a semantic structure, so that at the end of the project, the lecture materials will interactively support both on-site lectures and distance learning. Furthermore, case-based dialogue system will be provided that will help the students to learn how to practically cope with different nursing cases.

PI University Medical Center Rostock: Prof. Dr. med. Stefan Teipel

Funding body: Eu­ro­pean So­cial Fund (ESF)

More information about the project.

SMARTGEM - Smartphone supported migraine therapy

The SMARTGEM project aims to enable effective, time-saving and cost-saving treatment of common migraine headaches: patients can use their smartphone app (M-sense) to document their headaches and identify potential triggering factors.

PI University Medical Center Rostock: PD Dr. med. Tim Jürgens

Funding body: Innovationsfonds des Gemeinsamen Bundesauschuss 

More information about the project.

AgeGain - Senior citizens train their mental fitness

In the study AgeGain, cognitively healthy older people complete four weeks of computer-based cognitive training. The dementia researchers under the direction of Prof. Stefan Teipel at the University Medical Centre Rostock measure the participants’ cognitive performance, brain structure and functioning as well as physical activity. AgeGain aims at identifying the neurobiological signs that predict if a person is able to transfer the improvement in trained exercises to other tasks that have not been practiced. This is essential, since cognitive training is ultimately intended to enhance cognitive functions needed for activities of daily living, in order to maintain independency and social participation in old age. In participatory workshops, the AgeGain participants additionally get the opportunity to actively analyse their own data.

The study is conducted in collaboration with three centres: the University Medical Center Mainz, the University Hospital Cologne and the German Sport University Cologne. AgeGain started in 2016. It is funded for a duration of four years by the German Federal Ministry of Education and Research (BMBF) (grant number: 01GQ1425A).

PI University Medical Center Rostock: Prof. Dr. med. Stefan Teipel

Cerebral FGF21-resistance as cause of the obesity-associated neurodegeneration

Metabolic syndrome, which includes visceral obesity, elevated triglycerides, elevated fasting blood sugar, high blood pressure and a decrease in HDL-cholesterol levels, comprises the most common chronic physical illness in modern society. Hypercholesterolemia may exert a negative effect on cognitive performance. One hormone, which regulates carbohydrate and lipid homeostasis and therefore the body weight, is the Fibroblast Growth Factor 21 (FGF21).  

 

PI University Medical Center Rostock: PD Dr. rer. nat. Angela Kuhla

 

Funding body: DFG

 

More information and contact.

AHeaD – Künftige Aufgabenteilung von Pflegefachpersonen und Hausärzten in der ambulanten Demenzversorgung: Aufgaben, Akzeptanz, Qualifikation

The AHeaD study investigates how the outpatient care of people with dementia can be shaped in the future with a changed division of labor between nurses and general practitioners and is accepted by the specialist groups as well as by those affected and their relatives.

PI University Medical Center Rostock: Prof. Dr. med. Attila Altiner

Funding body: Innovationsfonds des Gemeinsamen Bundesauschuss 

Funding duration: May 2017 - April 2020

CRC 1270 ELAINE: C03 Deep brain stimulation in dystonia models: Biological implementation, approximation of stimulation parameters and analysis of mechanisms

The aim of this project is to clarify the mechanisms of action of deep brain stimulation in dystonia, to define stimulation targets and stimulation paradigms, and to identify therapeutic success markers. We hypothesise that deep brain stimulation improves pathophysiological processes of dystonia, specifically synaptic / cellular plasticity, inhibitory tone and network oscillations via specific network changes, depending on target structure and stimulation parameters. We will therefore analyse the underlying mechanisms of deep brain stimulation, narrow down effective stimulation parameters, identify early biomarkers of therapeutic outcome, and analyse and model the effects of deep brain stimulation on the extended basal ganglia network.

PI University Medical Center Rostock: Prof. Dr. med. Rüdiger Köhling

More information and contact.

CRC 1270 ELAINE: C04 Effects of deep brain stimulation on adult neurogenesis in a rat model of Parkinson`s disease: Mechanisms of action, stimulation parameters and correlation with behaviour

Parkinson's disease is characterised by typical motor symptoms and various non-motor symptoms such as depression and dementia, which are conceivably related to defective neuronal plasticity. Although deep brain stimulation is meanwhile a routine procedure in advanced Parkinson's disease, the mechanisms behind its effects on non-motor symptoms remain elusive. We here propose to investigate the mechanisms of deep-brain stimulation related to the interplay between cellular brain plasticity and non-motor symptoms in a rat model for Parkinson's disease. The results will contribute not only to the understanding of actions of deep-brain stimulation, but also to knowledge of the pathophysiological mechanisms underlying depression and cognitive dysfunction.

PI University Medical Center Rostock: Prof. Dr. med. Alexander Storch

More information and contact.

PubMed publications between CTNR members from two and more different institutes (highlighted in bold, sorted by publication month). Status: October 2022

2022

Siponimod ameliorates metabolic oligodendrocyte injury via the sphingosine-1 phosphate receptor 5.

Behrangi N, Heinig L, Frintrop L, Santrau E, Kurth J, Krause B, Atanasova D, Clarner T, Fragoulis A, Joksch M, Rudolf H, Meuth SG, Joost S, Kipp M. Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2204509119. doi: 10.1073/pnas.2204509119. Epub 2022 Sep 26. PMID: 36161894


Melanoma 2.0. Skin cancer as a paradigm for emerging diagnostic technologies, computational modelling and artificial intelligence.

Vera J, Lai X, Baur A, Erdmann M, Gupta S, Guttà C, Heinzerling L, Heppt MV, Kazmierczak PM, Kunz M, Lischer C, Pützer BM, Rehm M, Ostalecki C, Retzlaff J, Witt S, Wolkenhauer O, Berking C. Brief Bioinform. 2022 Oct 17:bbac433. doi: 10.1093/bib/bbac433. Online ahead of print. PMID: 36252807


Evaluation of the Synergistic Potential of Simultaneous Pan- or Isoform-Specific BET and SYK Inhibition in B-Cell Lymphoma: An In Vitro Approach.

Sender S, Sultan AW, Palmer D, Koczan D, Sekora A, Beck J, Schuetz E, Taher L, Brenig B, Fuellen G, Junghanss C, Murua Escobar H. Cancers (Basel). 2022 Sep 27;14(19):4691. doi: 10.3390/cancers14194691. PMID: 36230614


A conserved long-distance telomeric silencing mechanism suppresses mTOR signaling in aging human fibroblasts.

Jäger K, Mensch J, Grimmig ME, Neuner B, Gorzelniak K, Türkmen S, Demuth I, Hartmann A, Hartmann C, Wittig F, Sporbert A, Hermann A, Fuellen G, Möller S, Walter M. Sci Adv. 2022 Aug 19;8(33):eabk2814. doi: 10.1126/sciadv.abk2814. Epub 2022 Aug 17. PMID: 35977016


Protein Biomarkers in Blood Reflect the Interrelationships Between Stroke Outcome, Inflammation, Coagulation, Adhesion, Senescence and Cancer.

Fuellen G, Walter U, Henze L, Böhmert J, Palmer D, Lee S, Schmitt CA, Rudolf H, Kowald A. Cell Mol Neurobiol. 2022 Aug 11:1-12. doi: 10.1007/s10571-022-01260-1. Online ahead of print. PMID: 35953740


Spontaneous Hind Limb Paralysis Due to Acute Precursor B Cell Leukemia in RAG1-deficient Mice.

Feifei L, Richter A, Runge J, Keiler J, Hermann A, Kipp M, Joost S. J Mol Neurosci. 2022 Aug;72(8):1646-1655. doi: 10.1007/s12031-022-02025-7. Epub 2022 May 18. PMID: 35583713


Cognitive reserve protects ALS-typical cognitive domains: A longitudinal study.

Temp AGM, Kasper E, Machts J, Vielhaber S, Teipel S, Hermann A, Prudlo J. Ann Clin Transl Neurol. 2022 Aug;9(8):1212-1223. doi: 10.1002/acn3.51623. Epub 2022 Jul 22. PMID: 35866289


Differential Cellular Balance of Olfactory and Vomeronasal Epithelia in a Transgenic BACHD Rat Model of Huntington's Disease.

Krysewski LM, Power Guerra N, Glatzel A, Holzmann C, Antipova V, Schmitt O, Yu-Taeger L, Nguyen HP, Wree A, Witt M. Int J Mol Sci. 2022 Jul 10;23(14):7625. doi: 10.3390/ijms23147625. PMID: 35886975


Molecular Characterization of the Response to Conventional Chemotherapeutics in Pro-B-ALL Cell Lines in Terms of Tumor Relapse.

Gladbach YS, Sklarz LM, Roolf C, Beck J, Schütz E, Fuellen G, Junghanss C, Murua Escobar H, Hamed M. Genes (Basel). 2022 Jul 14;13(7):1240. doi: 10.3390/genes13071240. PMID: 35886023


[Assessment of General Family Functioning: Psychometric Evaluation of the German Version of the Brief Assessment of Family Functioning Scale].

Spitzer C, Lübke L, Göbel P, Müller S, Krogmann D, Brähler E, Reis O, Lincke L, Kölch M. Psychother Psychosom Med Psychol. 2022 Jul;72(7):292-298. doi: 10.1055/a-1692-8763. Epub 2021 Dec 15. PMID: 34911106


Physical Activity is Associated with Less Analgesic Use in Women Reporting Headache-A Cross-Sectional Study of the German Migraine and Headache Society (DMKG).

Müller B, Gaul C, Glass Ä, Reis O, Jürgens TP, Kropp P, Ruscheweyh R, Straube A, Brähler E, Förderreuther S, Dresler T. Pain Ther. 2022 Jun;11(2):545-560. doi: 10.1007/s40122-022-00362-4. Epub 2022 Feb 25. PMID: 35212968


Early Post-ischemic Brain Glucose Metabolism Is Dependent on Function of TLR2: a Study Using [18F]F-FDG PET-CT in a Mouse Model of Cardiac Arrest and Cardiopulmonary Resuscitation.

Bajorat R, Kurth J, Stenzel J, Vollmar B, Krause BJ, Reuter DA, Schuerholz T, Bergt S. Mol Imaging Biol. 2022 Jun;24(3):466-478. doi: 10.1007/s11307-021-01677-y. Epub 2021 Nov 15. PMID: 34779968


Cerebral venous sinus thrombosis after adenovirus-vectored COVID-19 vaccination: review of the neurological-neuroradiological procedure.

Wittstock M, Walter U, Volmer E, Storch A, Weber MA, Großmann A. Neuroradiology. 2022 May;64(5):865-874. doi: 10.1007/s00234-022-02914-z. Epub 2022 Feb 19. PMID: 35184205.


Lethal form of a late-onset aquaporin-4 antibody-positive NMOSD related to the immune checkpoint inhibitor nivolumab.

Weiss D, Cantré D, Zettl UK, Storch A, Prudlo J. J Neurol. 2022 May;269(5):2778-2780. doi: 10.1007/s00415-021-10913-y. Epub 2021 Nov 28. PMID: 34841443


Prediction of Disorientation by Accelerometric and Gait Features in Young and Older Adults Navigating in a Virtually Enriched Environment.

Teipel SJ, Amaefule CO, Lüdtke S, Görß D, Faraza S, Bruhn S, Kirste T. Front Psychol. 2022 Apr 25;13:882446. doi: 10.3389/fpsyg.2022.882446. eCollection 2022. PMID: 35548510


Dentate-nucleus gadolinium deposition on magnetic resonance imaging: ultrasonographic and clinical correlates in multiple sclerosis patients.

Kühn I, Maschke H, Großmann A, Hauenstein K, Weber MA, Zettl UK, Storch A, Walter U. Neurol Sci. 2022 Apr;43(4):2631-2639. doi: 10.1007/s10072-021-05702-4. Epub 2021 Nov 4. PMID: 34735650


Targeting pancreatic cancer with combinatorial treatment of CPI-613 and inhibitors of lactate metabolism.

Kumstel S, Schreiber T, Goldstein L, Stenzel J, Lindner T, Joksch M, Zhang X, Wendt EHU, Schönrogge M, Krause B, Vollmar B, Zechner D. PLoS One. 2022 Apr 22;17(4):e0266601. doi: 10.1371/journal.pone.0266601. eCollection 2022. PMID: 35452495


Headache in the Neurological Emergency Department-High Degree of Inadequate Documentation Calls for Structured Assessments.

Rimmele F, Janke J, Kropp P, Kasch R, Walter U, Jürgens TP. Front Neurol. 2022 Mar 24;13:847484. doi: 10.3389/fneur.2022.847484. eCollection 2022. PMID: 35401419


[Parental Stress: Psychometric Evaluation of the German Version of the Parental Stress Scale in the General Population].

Kölch M, Lübke L, Müller S, Reis O, Brähler E, Lincke L, Spitzer C. Psychother Psychosom Med Psychol. 2022 Mar 14. doi: 10.1055/a-1778-5316. Online ahead of print. PMID: 35287236


Affection of Respiratory Muscles in ALS and SMA.

Hermann W, Langner S, Freigang M, Fischer S, Storch A, Günther R, Hermann A. J Clin Med. 2022 Feb 22;11(5):1163. doi: 10.3390/jcm11051163. PMID: 35268254


Motor-Independent Cognitive Testing in Motor Degenerative Diseases.

Schmitz-Peiffer H, Aust E, Linse K, Rueger W, Joos M, Löhle M, Storch A, Hermann A. J Clin Med. 2022 Feb 3;11(3):814. doi: 10.3390/jcm11030814. PMID: 35160265


CT imaging-based approaches to cochlear duct length estimation-a human temporal bone study.

Breitsprecher T, Dhanasingh A, Schulze M, Kipp M, Dakah RA, Oberhoffner T, Dau M, Frerich B, Weber MA, Langner S, Mlynski R, Weiss NM. Eur Radiol. 2022 Feb;32(2):1014-1023. doi: 10.1007/s00330-021-08189-x. Epub 2021 Aug 31. PMID: 34463797


Functional MAOB Gene Intron 13 Polymorphism Predicts Dyskinesia in Parkinson's Disease.

Löhle M, Mangone G, Hermann W, Hausbrand D, Wolz M, Mende J, Reichmann H, Hermann A, Corvol JC, Storch A. Parkinsons Dis. 2022 Jan 20;2022:5597503. doi: 10.1155/2022/5597503. eCollection 2022. PMID: 35096365


Loss of "insight" into behavioral changes in ALS: Differences across cognitive profiles.

Temp AGM, Kasper E, Vielhaber S, Machts J, Hermann A, Teipel S, Prudlo J. Brain Behav. 2022 Jan;12(1):e2439. doi: 10.1002/brb3.2439. Epub 2021 Dec 2. PMID: 34855301


The Prognostic and Predictive Role of Xeroderma Pigmentosum Gene Expression in Melanoma.

Fischer S, Hamed M, Emmert S, Wolkenhauer O, Fuellen G, Thiem A. Front Oncol. 2022 Jan 31;12:810058. doi: 10.3389/fonc.2022.810058. eCollection 2022. PMID: 35174087


Olfactory Bulb D2/D3 Receptor Availability after Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson's Disease.

Alberts T, Antipova V, Holzmann C, Hawlitschka A, Schmitt O, Kurth J, Stenzel J, Lindner T, Krause BJ, Wree A, Witt M. Toxins (Basel). 2022 Jan 25;14(2):94. doi: 10.3390/toxins14020094. PMID: 35202123


The Molecular Subtype of Adult Acute Lymphoblastic Leukemia Samples Determines the Engraftment Site and Proliferation Kinetics in Patient-Derived Xenograft Models.

Richter A, Roolf C, Sekora A, Knuebel G, Krohn S, Lange S, Krebs V, Schneider B, Lakner J, Wittke C, Kiefel C, Jeremias I, Murua Escobar H, Vollmar B, Junghanss C. Cells. 2022 Jan 3;11(1):150. doi: 10.3390/cells11010150. PMID: 35011712 Free PMC article.


Establishment and Characterization of FusionRed Stable Transfected Canine Prostate Adenocarcinoma and Transitional Cell Carcinoma Cells.

Alnajjar S, Nolte I, Schille JT, Sender S, Trakoolju N, Perez SV, Zechner D, Vollmar B, Junghanss C, Murua Escobar H. In Vivo. 2022 Jan-Feb;36(1):170-179. doi: 10.21873/invivo.12688. PMID: 34972712