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Frontotemporal lobar degeneration with TDP-43 pathology

16. August 2021
ctnr

CTNR Lecture Series

Prof. Dr. Manuela Neumann

Director of the Department for Pathology and Neuropathology at University Hospital of Tuebingen and Group Leader of the section Molecular Neuropathology of Neurodegenerative Diseases at the DZNE Tübingen

Frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP): Advances in understanding the molecular basis of clinical and pathological heterogeneity

Abnormal accumulation of hyperphosphorylated TDP-43 defines the most common subtype of frontotemporal lobar degeneration (FTLD-TDP). FTLD-TDP can be further subclassified based on the types and cortical/subcortical distribution of neuronal and glial inclusions. The relevance of these pathological subtypes is supported by the presence of relatively specific clinical and genetic correlations. A crucial open question in the field is the molecular basis behind the huge clinical and neuropathological phenotypic variability. In analogy to prion diseases, a popular hypothesis is that the different patterns of pathology might be a reflection of biochemical differences in the pathological TDP-43 species. In my talk, I will present the pathological features, clinical and genetic correlations of the currently recognized FTLD-TDP subtypes and discuss novel insights into biochemical differences of TDP-43 species among FTLD-TDP subtypes with focus on phosphorylation.

16 August 2021, 16:00

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