Understanding how to prevent protein aggregation with age using C. elegans

19. June 2019

CTNR talk provided by the Translational Neurodegeneration Section "Albrecht Kossel", Dept. Neurology

Wednesday 19.06.2019, 11:00 – 12:00 Uhr
Seminar room 1.001, 1.OG, Altes Verwaltungsgebäude, Zentrum für Nervenheilkunde, Gehlsheimer Str. 20, 18147 Rostock

Speaker: Dr. sc. nat. Della C. David – Group leader, German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany
Host: Prof. Dr. Dr. Andreas Hermann, Translational Neurodegeneration Section "Albrecht Kossel", Dept. Neurology


Protein instability is an important hallmark of neurodegenerative diseases and ageing. Our group focuses on understanding the causes, the consequences and the regulation of aberrant protein aggregation during ageing. For this, we use mainly the nematode Caenorhabditis elegans, a simple short-lived organism ideal for ageing research. I will summarize our recent results describing how protein aggregation contributes to ageing and how the organism protects itself from aggregation both on a cellular level and in the extracellular space. Ultimately, understanding how to maintain a healthy proteome with age should lead to novel ways to delay or reverse ageing and potentially to treatments for neurodegenerative disorders.

3 most important recent papers:

Lechler MC, et al., and David DC. Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging. Cell Rep. 2017 Jan 10;18(2):454-467.
Groh N, et al.,  and David DC. Age-Dependent Protein Aggregation Initiates Amyloid-β Aggregation. Front Aging Neurosci. 2017 May 17;9:138. doi: 10.3389/fnagi.2017.00138. eCollection 2017. Recommended in F1000.
David DC et al.. Widespread protein aggregation as an inherent part of aging in C. elegans.  PLoS biol. 8 (8). Highlighted in: Nature, Research highlights: “Ageing: Proteins clump with age”, 466,  904 (2010)  Nature Methods, News in brief: “The aggregating proteome”, Nature Methods 7, 781 (2010).  Recommended three times in F1000.

If you would like to talk to the speaker, please get in contact with Andreas Hermann (andreas.hermann@med.uni-rostock.de).

Everybody is very welcome!